Synonyms: IN1228
Compound class:
Synthetic organic
Comment: ISO-1 is a prototypical inhibitor of the tautomerase activity of macrophage migration inhibitory factor (MIF) [3].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Bloom J, Metz C, Nalawade S, Casabar J, Cheng KF, He M, Sherry B, Coleman T, Forsthuber T, Al-Abed Y. (2016)
Identification of Iguratimod as an Inhibitor of Macrophage Migration Inhibitory Factor (MIF) with Steroid-sparing Potential. J Biol Chem, 291 (51): 26502-26514. [PMID:27793992] |
2. Cisneros JA, Robertson MJ, Valhondo M, Jorgensen WL. (2016)
Irregularities in enzyme assays: The case of macrophage migration inhibitory factor. Bioorg Med Chem Lett, 26 (12): 2764-2767. [PMID:27156768] |
3. Lubetsky JB, Dios A, Han J, Aljabari B, Ruzsicska B, Mitchell R, Lolis E, Al-Abed Y. (2002)
The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. J Biol Chem, 277 (28): 24976-82. [PMID:11997397] |
4. Vujicic M, Nikolic I, Krajnovic T, Cheng KF, VanPatten S, He M, Stosic-Grujicic S, Stojanovic I, Al-Abed Y, Saksida T. (2014)
Novel inhibitors of macrophage migration inhibitory factor prevent cytokine-induced beta cell death. Eur J Pharmacol, 740: 683-9. [PMID:24967533] |
5. Zapatero MC, Pérez P, Vázquez MJ, Colmenarejo G, de Los Frailes M, Ramón F. (2016)
Discovery of Novel Inhibitors of the Tautomerase Activity of Macrophage Migration Inhibitory Factor (MIF). J Biomol Screen, 21 (5): 446-58. [PMID:26933127] |