Synonyms: GYY4137
Compound class:
Synthetic organic
Comment: This is the parent molecule of a slow-release H2S donating molecule. It is used experimentally as the morpholine salt, morpholin-4-ium 4 methoxyphenyl(morpholino) phosphinodithioate (PubChem CID 53393943) [1], which is used as a pharmacological tool compound to study the biological functions of H2S in vitro and in vivo. H2S is a gasotransmitter that exhibits vasodilator and anti-hypertensive activity, and has anti-inflammatory effects.
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References |
1. A-González N, Castrillo A. (2011)
Liver X receptors as regulators of macrophage inflammatory and metabolic pathways. Biochim Biophys Acta, 1812 (8): 982-94. [PMID:21193033] |
2. Li L, Salto-Tellez M, Tan CH, Whiteman M, Moore PK. (2009)
GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat. Free Radic Biol Med, 47 (1): 103-13. [PMID:19375498] |