Synonyms: GYY4137
Compound class:
Synthetic organic
Comment: This is the parent molecule of a slow-release H2S donating molecule. It is used experimentally as the morpholine salt, morpholin-4-ium 4 methoxyphenyl(morpholino) phosphinodithioate (PubChem CID 53393943) [1], which is used as a pharmacological tool compound to study the biological functions of H2S in vitro and in vivo. H2S is a gasotransmitter that exhibits vasodilator and anti-hypertensive activity, and has anti-inflammatory effects.
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Immunopharmacology Comments |
In relation to its anti-inflammatory potential, GYY4137 inhibits TNF-α, IL-1β, and IL-6 production and reduces NF-κB activation, iNOS and COX-2 expression, and NO and PGE2 generation in LPS-challenged rats [2]. |