crovalimab

Home
Ligands
crovalimab

GtoPdb Ligand ID: 12790

Synonyms: RG-6107 | RG6107 | SKY59

Comment: Crovalimab (SKY59/RG6107) is a long-acting anti-C5 recycling monoclonal antibody [1-2]. The antibody is engineered to bind C5 in a pH-dependent manner. It binds strongly to C5 in the plasma, but in the acidic conditions within the endosome the antibody-C5 mmune complex dissociates; the free antibody is re-cycled and the C5 is trafficked to the lysosome for degradation. Crovalimab is proposed as a treatment for complement-mediated disorders such as paroxysmal nocturnal hemoglobinuria (PNH) and Lupus nephritis.

References
1. Fukuzawa T, Sampei Z, Haraya K, Ruike Y, Shida-Kawazoe M, Shimizu Y, Gan SW, Irie M, Tsuboi Y, Tai H et al.. (2017) Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases. Sci Rep, 7 (1): 1080. [PMID:28439081]
2. Sampei Z, Haraya K, Tachibana T, Fukuzawa T, Shida-Kawazoe M, Gan SW, Shimizu Y, Ruike Y, Feng S, Kuramochi T et al.. (2018) Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody. PLoS One, 13 (12): e0209509. [PMID:30592762]

References

1. Fukuzawa T, Sampei Z, Haraya K, Ruike Y, Shida-Kawazoe M, Shimizu Y, Gan SW, Irie M, Tsuboi Y, Tai H et al.. (2017)
Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases.
Sci Rep, 7 (1): 1080. [PMID:28439081]

2. Sampei Z, Haraya K, Tachibana T, Fukuzawa T, Shida-Kawazoe M, Gan SW, Shimizu Y, Ruike Y, Feng S, Kuramochi T et al.. (2018)
Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody.
PLoS One, 13 (12): e0209509. [PMID:30592762]