crovalimab   Click here for help

GtoPdb Ligand ID: 12790

Synonyms: RG-6107 | RG6107 | SKY59
Immunopharmacology Ligand
Compound class: Antibody
Comment: Crovalimab (SKY59/RG6107) is a long-acting anti-C5 recycling monoclonal antibody [1-2]. The antibody is engineered to bind C5 in a pH-dependent manner. It binds strongly to C5 in the plasma, but in the acidic conditions within the endosome the antibody-C5 mmune complex dissociates; the free antibody is re-cycled and the C5 is trafficked to the lysosome for degradation. Crovalimab is proposed as a treatment for complement-mediated disorders such as paroxysmal nocturnal hemoglobinuria (PNH) and Lupus nephritis.
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
complement C5 Hs Antibody Binding 9.8 pKd - 2
⤷ pKd 9.8 (Kd 1.5x10-10 M) [2]
Description: Binding affinity at pH7.4