Synonyms: compound 28 [PMID: 27344488] [2] | CYD-0618
Compound class:
Synthetic organic
Comment: CYD0618 is a derivative of the natural product oridonin [1]. Oridonin is an active compound found in the Rabdosia rubescen plant that is used in Chinese traditional medicine for its anti-inflammatory effects. CYD0618 has anti-fibrotic actions in the liver which are proposed to be mediated via inhibition of the NF-κB signalling pathway [1]. This compound also has reported antiproliferative activity in cancer cell lines [2].
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References |
1. Cummins CB, Wang X, Xu J, Hughes BD, Ding Y, Chen H, Zhou J, Radhakrishnan RS. (2018)
Antifibrosis Effect of Novel Oridonin Analog CYD0618 Via Suppression of the NF-κB Pathway. J Surg Res, 232: 283-292. [PMID:30463731] |
2. Ding Y, Ding C, Ye N, Liu Z, Wold EA, Chen H, Wild C, Shen Q, Zhou J. (2016)
Discovery and development of natural product oridonin-inspired anticancer agents. Eur J Med Chem, 122: 102-117. [PMID:27344488] |