Synonyms: compound 28 [PMID: 27344488] [2] | CYD-0618
Compound class:
Synthetic organic
Comment: CYD0618 is a derivative of the natural product oridonin [1]. Oridonin is an active compound found in the Rabdosia rubescen plant that is used in Chinese traditional medicine for its anti-inflammatory effects. CYD0618 has anti-fibrotic actions in the liver which are proposed to be mediated via inhibition of the NF-κB signalling pathway [1]. This compound also has reported antiproliferative activity in cancer cell lines [2].
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Bioactivity Comments |
CYD0618 induces cell cycle arrest and promotes apoptosis of activated hepatic stellate cells in vitro [1]. It appears to suppress degradation of the NF-κB regulatory protein IκBα (in the presence of LPS), and it inhibits expression of NF-κB target genes (IL-6, MCP-1, IL-1β, collagen 1). |