maresin 1   Click here for help

GtoPdb Ligand ID: 12056

Synonyms: 7R,14S-dihydroxydocosa-4Z,8E,10E,12Z,16Z,19Z-hexaenoic acid [5] | 7R-Maresin 1 | MaR1 | Maresin-1
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: Maresins are anti-inflammatory and pro-resolving lipid mediators that are biosynthesised from docosahexaenoic acid (DHA; an omega-3 fatty acid) by macrophages. Maresin 1 was the first family member to be identified [5-6].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 14
Topological polar surface area 77.76
Molecular weight 360.23
XLogP 4.58
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CC/C=C\C/C=C\C[C@@H](/C=C/C=C/C=C/[C@@H](C/C=C\CCC(=O)O)O)O
Isomeric SMILES CC/C=C\C/C=C\C[C@@H](/C=C/C=C/C=C/[C@@H](C/C=C\CCC(=O)O)O)O
InChI InChI=1S/C22H32O4/c1-2-3-4-5-6-10-15-20(23)16-11-7-8-12-17-21(24)18-13-9-14-19-22(25)26/h3-4,6-13,16-17,20-21,23-24H,2,5,14-15,18-19H2,1H3,(H,25,26)/b4-3-,8-7+,10-6-,13-9-,16-11+,17-12+/t20-,21-/m0/s1
InChI Key HLHYXXBCQOUTGK-LUSCUACYSA-N
References
1. Allen BL, Montague-Cardoso K, Simeoli R, Colas RA, Oggero S, Vilar B, McNaughton PA, Dalli J, Perretti M, Sher E et al.. (2020)
Imbalance of proresolving lipid mediators in persistent allodynia dissociated from signs of clinical arthritis.
Pain, 161 (9): 2155-2166. [PMID:32379221]
2. Chiang N, Libreros S, Norris PC, de la Rosa X, Serhan CN. (2019)
Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions.
J Clin Invest, 129 (12): 5294-5311. [PMID:31657786]
3. Fattori V, Pinho-Ribeiro FA, Staurengo-Ferrari L, Borghi SM, Rossaneis AC, Casagrande R, Verri Jr WA. (2019)
The specialised pro-resolving lipid mediator maresin 1 reduces inflammatory pain with a long-lasting analgesic effect.
Br J Pharmacol, 176 (11): 1728-1744. [PMID:30830967]
4. Saito-Sasaki N, Sawada Y, Nakamura M. (2022)
Maresin-1 and Inflammatory Disease.
Int J Mol Sci, 23 (3). DOI: 10.3390/ijms23031367 [PMID:35163291]
5. Serhan CN, Dalli J, Karamnov S, Choi A, Park CK, Xu ZZ, Ji RR, Zhu M, Petasis NA. (2012)
Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain.
FASEB J, 26 (4): 1755-65. [PMID:22253477]
6. Serhan CN, Yang R, Martinod K, Kasuga K, Pillai PS, Porter TF, Oh SF, Spite M. (2009)
Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions.
J Exp Med, 206 (1): 15-23. [PMID:19103881]