Compound class:
Synthetic organic
Comment: Inhibitor 1 inhibits the ORAI1 protein component of the CRAC channel [1]. The chemical structure represents a novel ORAI1-specific chemotype that is suitable for the development of more refined CRAC channel inhibitors.
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References |
1. Zhang HZ, Xu XL, Chen HY, Ali S, Wang D, Yu JW, Xu T, Nan FJ. (2015)
Discovery and structural optimization of 1-phenyl-3-(1-phenylethyl)urea derivatives as novel inhibitors of CRAC channel. Acta Pharmacol Sin, 36 (9): 1137-44. [PMID:26256403] |