ordesekimab

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ordesekimab

GtoPdb Ligand ID: 13046

Synonyms: AMG-714 | AMG714 | MAb146B7 | PRV-015

Comment: Ordesekimab (AMG714, formerly PRV-015) is a fully human anti-IL-15 monoclonal antibody [1]. It binds to Il-15-IL-15Rα complexes on monocytes and disrupts interaction of the cytokine-bound receptor α subunit with the IL-2Rβ and common γ chains of the IL-15 receptor complex that is necessary for receptor activation and downstream signalling.

Summary
Biological activity
Clinical data
References
Immunopharmacology

Immunopharmacology Comments
Blocking IL-15-mediated immune activation is under scrutiny for therapeutic efficacy for the treatment of IL-15-driven autoimmune diseases.

Immunopharmacology Comments

Blocking IL-15-mediated immune activation is under scrutiny for therapeutic efficacy for the treatment of IL-15-driven autoimmune diseases.