Synonyms: ADX-102 | ADX102 | example 5 [WO2018039197A1] | NS-2 | NS2 [1]
Compound class:
Synthetic organic
Comment: Reproxalap is a novel small molecule that acts as a molecular trap for pro-inflammatory Reactive Aldehyde Species (RASP) that was developed by Aldeyra Therapeutics. Reproxalap (as example 5; NS2) and its uses are claimed in Aldeyra patent WO2018039197A1 [1].
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Immunopharmacology Comments |
RASP are reactive molecules (formed by lipid peroxidation, alcohol oxidation, polyamine and glucose metabolism) that activate pro-inflammatory mediators. By binding and sequestering RASP, reproxalap produces anti-inflammatory effects that are being evaluated for efficacy in the treatrment of occular inflammation. |