Synonyms: ADX-102 | ADX102 | example 5 [WO2018039197A1] | NS-2 | NS2 [1]
Compound class:
Synthetic organic
Comment: Reproxalap is a novel small molecule that acts as a molecular trap for pro-inflammatory Reactive Aldehyde Species (RASP) that was developed by Aldeyra Therapeutics. Reproxalap (as example 5; NS2) and its uses are claimed in Aldeyra patent WO2018039197A1 [1].
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Bioactivity Comments |
ADX-102 is reported to bind covalently to aldehydes including malondialdehyde and 4-hydroxynonenal (a TRPA1 channel activator), which are both known to mediate inflammatory pain. Patent disclosures show that the compound forms an adduct with 4-hydroxynonenal (determined by HPLC), and reduces formation of the toxic ocular aldehyde metabolite A2E in vitro [1]. |
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