Synonyms: ONC-201 | TIC-10 | TIC10
Compound class:
Synthetic organic
Comment: ONC201 (also known as TIC10 [2]) was originally discovered as a TRAIL receptor inducer and as an orally active dual Akt/ERK inhibitor [1] It exerts potent anti-tumour effects.
Note that although [1] and [2] are published by the same research group, both articles show different isomers of the chemical structure. We show the structure from their 2016 paper, which introduces ONC201 as the first-in-class imipridone anti-cancer compound [1]. PubChem CID 336423 represents the alternative isomer as depicted in the 2013 paper [2]. ONC201 was later reported as an allosteric activator of the mitochondrial protease caseinolytic protease P (ClpP) [4]. ClpP is an oncology drug target [3]. |
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Bioactivity Comments |
ONC201 exhibits a dose-dependent anti-metastasis effect, and inhibits cancer cell migration and invasion. These effects are dependent on increased recruitment of natural killer cells to the tumour microenvironment, and are indicative of a novel mechanism for immune stimulation that produces anti-cancer activity [5]. |
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