ACKR2 | Chemokine receptors | IUPHAR Guide to IMMUNOPHARMACOLOGY

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ACKR2

  Target has curated data in GtoImmuPdb

Target id: 314

Nomenclature: ACKR2

Family: Chemokine receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
class A G protein-coupled receptor: Non-signalling 7TM chemokine-binding protein
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 384 3p21.3 ACKR2 atypical chemokine receptor 2
Mouse 7 378 9 F4 Ackr2 atypical chemokine receptor 2
Rat 7 382 8q32 Ackr2 atypical chemokine receptor 2
Previous and Unofficial Names
CCR10 | CCR9 | CMBRK9 | C-C chemokine receptor D6 | chemokine binding protein 2 | CMKBR9
Database Links
Specialist databases
GPCRDB ackr2_human (Hs), ackr2_mouse (Mm), ackr2_rat (Rn)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Endogenous agonists (Human)
CCL2 (CCL2, P13500), CCL3 (CCL3, P10147), CCL4 (CCL4, P13236), CCL5 (CCL5, P13501), CCL7 (CCL7, P80098), CCL8 (CCL8, P80075), CCL11 (CCL11, P51671), CCL13 (CCL13, Q99616), CCL14 (CCL14, Q16627), CCL17 (CCL17, Q92583), CCL22 (CCL22, O00626)
Immunopharmacology Comments
ACKR2 is one of more than 20 distinct chemokine receptors expressed in human leukocytes. Chemokines primarily act to promote leukocyte chemotaxis to sites of inflammation.
Immuno Process Associations
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes
GO:0005044 scavenger receptor activity IMP
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes
GO:0004950 chemokine receptor activity TAS
GO:0016493 C-C chemokine receptor activity IBA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 2 GO processes
GO:0004950 chemokine receptor activity TAS
GO:0016493 C-C chemokine receptor activity IBA
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0006954 inflammatory response IEA
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Ccbp2tm1Gjg Ccbp2tm1Gjg/Ccbp2tm1Gjg
involves: 129/Sv * C57BL/6
MGI:1891697  MP:0001194 dermatitis PMID: 15750596 
Ccbp2tm1Gjg Ccbp2tm1Gjg/Ccbp2tm1Gjg
involves: 129/Sv * C57BL/6
MGI:1891697  MP:0001846 increased inflammatory response PMID: 15789340 

Contributors

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How to cite this page

Philip M. Murphy, Francoise Bachelerie, Adit Ben-Baruch, Israel F. Charo, Christophe Combadiere, Joshua M. Farber, Reinhold Förster, Gerard J. Graham, Rebecca Hills, Richard Horuk, Massimo Locati, Andrew D. Luster, Alberto Mantovani, Kouji Matsushima, Amy E. Monaghan, Georgios L. Moschovakis, Robert J. B. Nibbs, Hisayuki Nomiyama, Joost J. Oppenheim, Christine A. Power, Amanda E. I. Proudfoot , Mette M. Rosenkilde, Antal Rot, Silvano Sozzani, Marcus Thelen, Osamu Yoshie, Albert Zlotnik.
Chemokine receptors: ACKR2. Last modified on 24/02/2017. Accessed on 25/05/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=314.