moxetumomab pasudotox   Click here for help

GtoPdb Ligand ID: 7675

Synonyms: CAT-8015 | GCR-8015 | HA22 | Lumoxiti® | moxetumomab pasudotox-tdfk
Approved drug Immunopharmacology Ligand
moxetumomab pasudotox is an approved drug (FDA (2018), EMA (2021))
Compound class: Antibody
Comment: Peptide sequence information for this antibody is available from its IMGT/mAb-DB link. The moxetumomab monoclonal has been mutated to increase affinity for CD22 [6] (patent WO2003027135[1]), and the antibody is fused to a 38 KDa fragment of Pseudomonas exotoxin-A (PE38) [2,4] (patent US7982011 [5]). The Uniprot accession for Pseudomonas exotoxin-A is P11439.
Click here for help
Classification Click here for help
Compound class Antibody
Ligand families/groups Immune checkpoint modulators
Approved drug? Yes (FDA (2018), EMA (2021))
International Nonproprietary Names Click here for help
INN number INN
9236 moxetumomab pasudotox
Synonyms Click here for help
CAT-8015 | GCR-8015 | HA22 | Lumoxiti® | moxetumomab pasudotox-tdfk
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 198
Other databases
ChEMBL Ligand CHEMBL1743043
GtoPdb PubChem SID 223366010
Search PubMed clinical trials moxetumomab pasudotox
Search PubMed titles moxetumomab pasudotox
Search PubMed titles/abstracts moxetumomab pasudotox
Wikipedia Moxetumomab pasudotox