moxetumomab pasudotox   Click here for help

GtoPdb Ligand ID: 7675

Synonyms: CAT-8015 | GCR-8015 | HA22 | Lumoxiti® | moxetumomab pasudotox-tdfk
Approved drug Immunopharmacology Ligand
moxetumomab pasudotox is an approved drug (FDA (2018), EMA (2021))
Compound class: Antibody
Comment: Peptide sequence information for this antibody is available from its IMGT/mAb-DB link. The moxetumomab monoclonal has been mutated to increase affinity for CD22 [6] (patent WO2003027135[1]), and the antibody is fused to a 38 KDa fragment of Pseudomonas exotoxin-A (PE38) [2,4] (patent US7982011 [5]). The Uniprot accession for Pseudomonas exotoxin-A is P11439.
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Immunopharmacology Comments
Moxetumomab pasudotox is an immune checkpoint modulator that delivers a toxic payload to target cancer cells.