CCL4   

GtoPdb Ligand ID: 757

Synonyms: HC21 | macrophage inflammatory protein-1β | MIP-1β
Comment: CCL4 is a CC family chemokine more commonly referred to as macrophage inflammatory protein-1β or MIP-1β. It acts in a dimer with CCL3 (MIP-1α) [1].
Species: Human
References
1. A-González N, Castrillo A. (2011)
Liver X receptors as regulators of macrophage inflammatory and metabolic pathways.
Biochim. Biophys. Acta, 1812 (8): 982-94. [PMID:21193033]
2. Bystry RS, Aluvihare V, Welch KA, Kallikourdis M, Betz AG. (2001)
B cells and professional APCs recruit regulatory T cells via CCL4.
Nat. Immunol., 2 (12): 1126-32. [PMID:11702067]
3. Chou CC, Fine JS, Pugliese-Sivo C, Gonsiorek W, Davies L, Deno G, Petro M, Schwarz M, Zavodny PJ, Hipkin RW. (2002)
Pharmacological characterization of the chemokine receptor, hCCR1 in a stable transfectant and differentiated HL-60 cells: antagonism of hCCR1 activation by MIP-1beta.
Br. J. Pharmacol., 137 (5): 663-75. [PMID:12381680]
4. Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P. (1995)
Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells.
Science, 270 (5243): 1811-5. [PMID:8525373]
5. Combadiere C, Ahuja SK, Van Damme J, Tiffany HL, Gao JL, Murphy PM. (1995)
Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B.
J Biol Chem, 270: 29671-29675. [PMID:8530354]
6. Napier C, Sale H, Mosley M, Rickett G, Dorr P, Mansfield R, Holbrook M. (2005)
Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human.
Biochem. Pharmacol., 71 (1-2): 163-72. [PMID:16298345]
7. Ren M, Guo Q, Guo L, Lenz M, Qian F, Koenen RR, Xu H, Schilling AB, Weber C, Ye RD et al.. (2010)
Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme.
EMBO J., 29 (23): 3952-66. [PMID:20959807]
8. Ruffing N, Sullivan N, Sharmeen L, Sodroski J, Wu L. (1998)
CCR5 has an expanded ligand-binding repertoire and is the primary receptor used by MCP-2 on activated T cells.
Cell. Immunol., 189 (2): 160-8. [PMID:9790730]
9. Sherry B, Tekamp-Olson P, Gallegos C, Bauer D, Davatelis G, Wolpe SD, Masiarz F, Coit D, Cerami A. (1988)
Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta.
J. Exp. Med., 168 (6): 2251-9. [PMID:3058856]