selectin P ligand   Click here for help

GtoPdb Ligand ID: 10014

Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: P-selectin glycoprotein ligand 1 (PSLG-1) is a single transmembrane proteoglycan that is expressed on leukocyte membranes. It interacts with E-, P- and L-selectins on endothelial cell surfaces.
We provide the amino acid sequence for the mature form of the ligand (amino acids 42-412), without its signal and propeptide sequences.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Immunopharmacology Comments
P-selectin glycoprotein ligand 1 (PSLG-1) is a leukocyte expressed membrane proteoglycan that interacts with E-, P- and L-selectins on endothelial cell surfaces to mediate the rapid rolling of leukocytes over vascular surfaces that is essential for initiating the recruitment of leukocytes to inflammatory sites. The PSLG-1/P-selectin interaction is being investigated as a novel anti-inflammatory mechanism for the development of new therapies applicable to autoimmune diseases, transplant rejection, allergic conditions, or T cell cancer [1-2].