selectin P ligand   

GtoPdb Ligand ID: 10014

Comment: P-selectin glycoprotein ligand 1 (PSLG-1) is a single transmembrane proteoglycan that is expressed on leukocyte membranes. It interacts with E-, P- and L-selectins on endothelial cell surfaces.
We provide the amino acid sequence for the mature form of the ligand (amino acids 42-412), without its signal and propeptide sequences.
Species: Human
Immunopharmacology Comments
P-selectin glycoprotein ligand 1 (PSLG-1) is a leukocyte expressed membrane proteoglycan that interacts with E-, P- and L-selectins on endothelial cell surfaces to mediate the rapid rolling of leukocytes over vascular surfaces that is essential for initiating the recruitment of leukocytes to inflammatory sites. The PSLG-1/P-selectin interaction is being investigated as a novel anti-inflammatory mechanism for the development of new therapies applicable to autoimmune diseases, transplant rejection, allergic conditions, or T cell cancer [1-2].