selectin P ligand   

GtoPdb Ligand ID: 10014

Comment: P-selectin glycoprotein ligand 1 (PSLG-1) is a single transmembrane proteoglycan that is expressed on leukocyte membranes. It interacts with E-, P- and L-selectins on endothelial cell surfaces.
We provide the amino acid sequence for the mature form of the ligand (amino acids 42-412), without its signal and propeptide sequences.
Species: Human
Selectivity at other protein targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
P-selectin (CD62) Hs None Binding 6.5 pKd - 3
pKd 6.5 (Kd 3.2x10-7 M) [3]
Other ligands which bind to or alter the activity of this ligand
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Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
AbGn-168H Hs Antibody Agonist 11.5 pKd - 2
pKd 11.5 (Kd 3x10-12 M) [2]
Description: Kd calculated as the inverse of the Ka (333 nM) presented in the patent reference. Ka was calculated from a competition binding assay that measured displacement of murine anti-PSGL-1 antibody 15A7 by AbGn-168H from purified PSGL-1.