selectin P ligand   Click here for help

GtoPdb Ligand ID: 10014

Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: P-selectin glycoprotein ligand 1 (PSLG-1) is a single transmembrane proteoglycan that is expressed on leukocyte membranes. It interacts with E-, P- and L-selectins on endothelial cell surfaces.
We provide the amino acid sequence for the mature form of the ligand (amino acids 42-412), without its signal and propeptide sequences.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
selectin P (CD62) Ligand is endogenous in the given species Hs None Binding 6.5 pKd - 3
⤷ pKd 6.5 (Kd 3.2x10-7 M) [3]
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
AbGn-168H Peptide Primary target of this compound Hs Antibody Agonist 11.5 pKd - 2
⤷ pKd 11.5 (Kd 3x10-12 M) [2]
Description: Kd calculated as the inverse of the Ka (333 nM) presented in the patent reference. Ka was calculated from a competition binding assay that measured displacement of murine anti-PSGL-1 antibody 15A7 by AbGn-168H from purified PSGL-1.