selectin P ligand   Click here for help

GtoPdb Ligand ID: 10014

Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: P-selectin glycoprotein ligand 1 (PSLG-1) is a single transmembrane proteoglycan that is expressed on leukocyte membranes. It interacts with E-, P- and L-selectins on endothelial cell surfaces.
We provide the amino acid sequence for the mature form of the ligand (amino acids 42-412), without its signal and propeptide sequences.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Lin R-H Wu C-H, Hsu P-L. (2003)
Modulators of P-selectin glycoprotein ligand 1.
Patent number: US20030049252A1. Assignee: AbGenomics Co. Priority date: 03/08/2001. Publication date: 13/03/2003.
2. Lin R-H, Chang CN, Chen P-J, Huang C-C. (2009)
Anti-PSGL-1 antibodies.
Patent number: US7604800B2. Assignee: AbGenomics Cooperatief UA. Priority date: 10/05/2004. Publication date: 20/10/2009.
3. Mehta P, Cummings RD, McEver RP. (1998)
Affinity and kinetic analysis of P-selectin binding to P-selectin glycoprotein ligand-1.
J Biol Chem, 273 (49): 32506-13. [PMID:9829984]