CCL20   Click here for help

GtoPdb Ligand ID: 808

Synonyms: LARC | liver and activation-regulated chemokine | macrophage inflammatory protein-3α | MIP-3α
Immunopharmacology Ligand
Comment: CCL20 is a CC family chemokine. It is the only identified ligand for the chemokine receptor CCR6.
Species: Human
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Natural/Endogenous Targets
Target
CCR6
CXCR3
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
CXCR3 Ligand is endogenous in the given species Hs Agonist Full agonist 6.8 pKi - 9
pKi 6.8 [9]
CCR6 Ligand is endogenous in the given species Hs Agonist Full agonist 7.9 – 8.5 pIC50 - 1,3,8
pIC50 7.9 – 8.5 [1,3,8]
Other ligands which bind to or alter the activity of this ligand
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Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
GSK3050002 Peptide Primary target of this compound Hs Antibody Binding 10.3 pKd - 4
pKd 10.3 (Kd 4.8x10-11 M) [4]
Description: Binding to human CCL20.