CCL20   Click here for help

GtoPdb Ligand ID: 808

Synonyms: LARC | liver and activation-regulated chemokine | macrophage inflammatory protein-3α | MIP-3α
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: CCL20 is a CC family chemokine. It is the only identified ligand for the chemokine receptor CCR6.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Ai LS, Liao F. (2002)
Mutating the four extracellular cysteines in the chemokine receptor CCR6 reveals their differing roles in receptor trafficking, ligand binding, and signaling.
Biochemistry, 41 (26): 8332-41. [PMID:12081481]
2. Arima Y, Harada M, Kamimura D, Park JH, Kawano F, Yull FE, Kawamoto T, Iwakura Y, Betz UA, Márquez G et al.. (2012)
Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier.
Cell, 148 (3): 447-57. [PMID:22304915]
3. Baba M, Imai T, Nishimura M, Kakizaki M, Takagi S, Hieshima K, Nomiyama H, Yoshie O. (1997)
Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC.
J Biol Chem, 272 (23): 14893-8. [PMID:9169459]
4. Bouma G, Zamuner S, Hicks K, Want A, Oliveira J, Choudhury A, Brett S, Robertson D, Felton L, Norris V et al.. (2017)
CCL20 neutralization by a monoclonal antibody in healthy subjects selectively inhibits recruitment of CCR6+ cells in an experimental suction blister.
Br J Clin Pharmacol, 83 (9): 1976-1990. [PMID:28295451]
5. Celis R, Planell N, Fernández-Sueiro JL, Sanmartí R, Ramírez J, González-Álvaro I, Pablos JL, Cañete JD. (2012)
Synovial cytokine expression in psoriatic arthritis and associations with lymphoid neogenesis and clinical features.
Arthritis Res Ther, 14 (2): R93. [PMID:22541888]
6. Homey B, Dieu-Nosjean MC, Wiesenborn A, Massacrier C, Pin JJ, Oldham E, Catron D, Buchanan ME, Müller A, deWaal Malefyt R et al.. (2000)
Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and CC chemokine receptor 6 in psoriasis.
J Immunol, 164 (12): 6621-32. [PMID:10843722]
7. Kaser A, Ludwiczek O, Holzmann S, Moschen AR, Weiss G, Enrich B, Graziadei I, Dunzendorfer S, Wiedermann CJ, Mürzl E et al.. (2004)
Increased expression of CCL20 in human inflammatory bowel disease.
J Clin Immunol, 24 (1): 74-85. [PMID:14997037]
8. Power CA, Church DJ, Meyer A, Alouani S, Proudfoot AE, Clark-Lewis I, Sozzani S, Mantovani A, Wells TN. (1997)
Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3alpha from lung dendritic cells.
J Exp Med, 186 (6): 825-35. [PMID:9294137]
9. Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. (1998)
Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.
J Biol Chem, 273 (29): 18288-91. [PMID:9660793]