CCL20   Click here for help

GtoPdb Ligand ID: 808

Synonyms: LARC | liver and activation-regulated chemokine | macrophage inflammatory protein-3α | MIP-3α
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: CCL20 is a CC family chemokine. It is the only identified ligand for the chemokine receptor CCR6.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Immunopharmacology Comments
CCL20 acts via the G protein-coupled chemokine receptor CCR6. CCL20 expression is detected in peripheral blood lymphocytes, lymph nodes, liver, appendix, and fetal lung, and is increased by microbial lipopolysaccharide and inflammatory cytokines (e.g. TNF and IFN-γ). IL-10 downregulates CCL20 expression. It is a potent chemoattractant for monocytes, but is much less potent for neutrophil attraction. CCL20 and its receptor CCR6 are up-regulated in tissues of patients with chronic inflammatory conditions (e.g. psoriasis, arthritic conditions and inflammatory bowel disease) [5-7]. CCL20 may also be relevant for autoimmune pathogenesis of the central nervous system [2].