Synonyms: PegIntron® | Sylatron®
peginterferon alfa-2b is an approved drug (EMA (2000), FDA (2001))
Compound class:
Peptide
Comment: Peginterferon alfa-2b is a pegylated interferon protein. Conjugation with polyethylene glycol (PEG) is a strategy commonly used to protect peptide drugs from in vivo proteolytic breakdown to increase their biological half-life and duration of action.
Peginterferon alfa-2b is on the World Health Organisation's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019). |
Bioactivity Comments |
As this drug is an interferon α analogue it will interact with the interferon-α/β receptor (IFNAR) as would the endogenous ligand. We have tagged the interferon α/β receptor 1 (IFNAR1- ligand binding subunit) and IFNAR (heterodimeric receptor) as primary drug targets, despite a lack of available affinity data. |
Selectivity at catalytic receptors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
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