Synonyms: PegIntron® | Sylatron®
peginterferon alfa-2b is an approved drug (EMA (2000), FDA (2001))
Compound class:
Peptide
Comment: Peginterferon alfa-2b is a pegylated interferon protein. Conjugation with polyethylene glycol (PEG) is a strategy commonly used to protect peptide drugs from in vivo proteolytic breakdown to increase their biological half-life and duration of action.
Peginterferon alfa-2b is on the World Health Organisation's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019). |
References |
1. Sangfelt O, Erickson S, Castro J, Heiden T, Einhorn S, Grandér D. (1997)
Induction of apoptosis and inhibition of cell growth are independent responses to interferon-alpha in hematopoietic cell lines. Cell Growth Differ, 8 (3): 343-52. [PMID:9056677] |
2. Ward AC, Touw I, Yoshimura A. (2000)
The Jak-Stat pathway in normal and perturbed hematopoiesis. Blood, 95 (1): 19-29. [PMID:10607680] |