peginterferon alfa-2b

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Ligands
peginterferon alfa-2b

GtoPdb Ligand ID: 7462

Synonyms: PegIntron® | Sylatron®

peginterferon alfa-2b is an approved drug (EMA (2000), FDA (2001))

Compound class: Peptide or derivative

Comment: Peginterferon alfa-2b is a pegylated interferon protein. Conjugation with polyethylene glycol (PEG) is a strategy commonly used to protect peptide drugs from in vivo proteolytic breakdown to increase their biological half-life and duration of action.
Peginterferon alfa-2b is on the World Health Organisation's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019).

References
1. Sangfelt O, Erickson S, Castro J, Heiden T, Einhorn S, Grandér D. (1997) Induction of apoptosis and inhibition of cell growth are independent responses to interferon-alpha in hematopoietic cell lines. Cell Growth Differ, 8 (3): 343-52. [PMID:9056677]
2. Ward AC, Touw I, Yoshimura A. (2000) The Jak-Stat pathway in normal and perturbed hematopoiesis. Blood, 95 (1): 19-29. [PMID:10607680]

References

1. Sangfelt O, Erickson S, Castro J, Heiden T, Einhorn S, Grandér D. (1997)
Induction of apoptosis and inhibition of cell growth are independent responses to interferon-alpha in hematopoietic cell lines.
Cell Growth Differ, 8 (3): 343-52. [PMID:9056677]

2. Ward AC, Touw I, Yoshimura A. (2000)
The Jak-Stat pathway in normal and perturbed hematopoiesis.
Blood, 95 (1): 19-29. [PMID:10607680]