Synonyms: PegIntron® | Sylatron®
peginterferon alfa-2b is an approved drug (EMA (2000), FDA (2001))
Compound class:
Peptide
Comment: Peginterferon alfa-2b is a pegylated interferon protein. Conjugation with polyethylene glycol (PEG) is a strategy commonly used to protect peptide drugs from in vivo proteolytic breakdown to increase their biological half-life and duration of action.
Peginterferon alfa-2b is on the World Health Organisation's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019). |
Chemical Modification | |
Covalently conjugated with monomethoxy polyethylene glycol (PEG) to reduce proteolytic cleavage and thereby increase the biological half-life of the interferon protein. |