Interferon-α/β receptor | Interferon receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Interferon-α/β receptor

  Target has curated data in GtoImmuPdb

Target id: 1898

Nomenclature: Interferon-α/β receptor

Family: Interferon receptor family

Quaternary Structure: Subunits
interferon α/β receptor 1 (Ligand-binding subunit)
Interferon α/β receptor 2 (Other subunit)
Previous and Unofficial Names
Interferon-α/β 1/2 heteromer
Natural/Endogenous Ligands
IFN-α1/13 {Sp: Human}
IFN-α10 {Sp: Human}
IFN-α14 {Sp: Human}
IFN-α16 {Sp: Human}
IFN-α17 {Sp: Human}
IFN-α2 {Sp: Human}
IFN-α21 {Sp: Human}
IFN-α4 {Sp: Human}
IFN-α5 {Sp: Human}
IFN-α6 {Sp: Human}
IFN-α7 {Sp: Human}
IFN-α8 {Sp: Human}
IFN-β {Sp: Human}
IFN-κ {Sp: Human}
IFN-ω {Sp: Human}

Download all structure-activity data for this target as a CSV file

Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
IFN-α1/13 {Sp: Human} Hs Agonist - -
IFN-α10 {Sp: Human} Hs Agonist - -
IFN-α14 {Sp: Human} Hs Agonist - -
IFN-α16 {Sp: Human} Hs Agonist - -
IFN-α17 {Sp: Human} Hs Agonist - -
IFN-α2 {Sp: Human} Hs Agonist - -
IFN-α21 {Sp: Human} Hs Agonist - -
IFN-α4 {Sp: Human} Hs Agonist - -
IFN-α5 {Sp: Human} Hs Agonist - -
IFN-α6 {Sp: Human} Hs Agonist - -
IFN-α7 {Sp: Human} Hs Agonist - -
IFN-α8 {Sp: Human} Hs Agonist - -
IFN-β {Sp: Human} Hs Agonist - -
IFN-κ {Sp: Human} Hs Agonist - -
IFN-ω {Sp: Human} Hs Agonist - -
peginterferon alfa-2b Hs Agonist - - 1
Immunopharmacology Comments
The interferon-α/β receptor has multiple endogenous ligands, including a number IFN-αs, and interferons β, κ and ω. The functional receptor is a heterodimer of interferon α/β receptor 1 and interferon α/β receptor 2.


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1. Ward AC, Touw I, Yoshimura A. (2000) The Jak-Stat pathway in normal and perturbed hematopoiesis. Blood, 95 (1): 19-29. [PMID:10607680]

How to cite this page

Interferon receptor family: Interferon-α/β receptor. Last modified on 10/04/2017. Accessed on 20/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY,