glycopyrrolate

Ligand id: 7459

Name: glycopyrrolate

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: glycopyrronium

Structure and Physico-chemical Properties

2D Structure
Click here for structure editor
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 46.53
Molecular weight 318.21
XLogP 2.59
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Glycopyrrolate has high, equipotent affinity for all muscarinic acetylcholine receptor subtypes (M1-5) [2].
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
M1 receptor Hs Antagonist Antagonist 9.9 pIC50 - 2
⤷ pIC50 9.9 (IC50 1.26x10-10 M) [2]
Description: Assay uses glycopyrronium bromide
M4 receptor Hs Antagonist Antagonist 9.8 pIC50 - 2
⤷ pIC50 9.8 (IC50 1.58x10-10 M) [2]
Description: Assay uses glycopyrronium bromide
M5 receptor Hs Antagonist Antagonist 9.7 pIC50 - 2
⤷ pIC50 9.7 (IC50 2x10-10 M) [2]
M3 receptor Hs Antagonist Antagonist 9.6 pIC50 - 2
⤷ pIC50 9.6 (IC50 2.51x10-10 M) [2]
Description: Assay uses glycopyrronium bromide
M2 receptor Hs Antagonist Antagonist 9.3 pIC50 - 2
⤷ pIC50 9.3 (IC50 5.01x10-10 M) [2]
Description: Assay uses glycopyrronium bromide