Ligand id: 7459

Name: glycopyrrolate

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View more information in the IUPHAR Pharmacology Education Project: glycopyrronium

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 46.53
Molecular weight 318.21
XLogP 2.59
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Hansel TT, Neighbour H, Erin EM, Tan AJ, Tennant RC, Maus JG, Barnes PJ. (2005)
Glycopyrrolate causes prolonged bronchoprotection and bronchodilatation in patients with asthma.
Chest, 128 (4): 1974-9. [PMID:16236844]
2. Stocks MJ, Alcaraz L, Bailey A, Bowers K, Donald D, Edwards H, Hunt F, Kindon N, Pairaudeau G, Theaker J et al.. (2010)
The discovery of new spirocyclic muscarinic M3 antagonists.
Bioorg. Med. Chem. Lett., 20 (24): 7458-61. [PMID:21036043]
3. Tzelepis G, Komanapolli S, Tyler D, Vega D, Fulambarker A. (1996)
Comparison of nebulized glycopyrrolate and metaproterenol in chronic obstructive pulmonary disease.
Eur. Respir. J., 9 (1): 100-3. [PMID:8834341]