glycopyrrolate [Ligand Id: 7459] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1201335 (Glycopyrronium)
  • M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
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  • M3 receptor/Muscarinic acetylcholine receptor M3 in Human [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
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  • M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229]
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  • M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
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  • M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
GtoPdb Assay uses glycopyrronium bromide - 9.3 pIC50 0.5 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 7458-61 [PMID:21036043]
ChEMBL Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs B 9.8 pIC50 0.16 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 7440-7446 [PMID:22047691]
M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
ChEMBL Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs B 9.6 pIC50 0.25 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 7440-7446 [PMID:22047691]
GtoPdb Assay uses glycopyrronium bromide - 9.6 pIC50 0.25 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 7458-61 [PMID:21036043]
ChEMBL Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method B 9.9 pIC50 0.13 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 6248-6253 [PMID:24144851]
M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229]
GtoPdb Assay uses glycopyrronium bromide - 9.9 pIC50 0.13 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 7458-61 [PMID:21036043]
M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
GtoPdb Assay uses glycopyrronium bromide - 9.8 pIC50 0.16 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 7458-61 [PMID:21036043]
M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912]
GtoPdb - - 9.7 pIC50 0.2 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 7458-61 [PMID:21036043]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]