tiotropium   Click here for help

GtoPdb Ligand ID: 367

Synonyms: BA-679-BR | Spiriva®
Approved drug Immunopharmacology Ligand
tiotropium is an approved drug (FDA (2004))
Compound class: Synthetic organic
Comment: We have chosen to display the structure of the parent compound, tiotropium, as this reflects the compound used in the experimental data listed under the 'biological activity' tab, and the links in the table above also represent the parent compound. However, the INN-assigned compound is in complex with bromide, the approved drug is also administered in this preparation. Note that the activity data in PubChem for this compound is split between the parent and the preparation with bromide.
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View more information in the IUPHAR Pharmacology Education Project: tiotropium

2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 115.54
Molecular weight 392.1
XLogP 0.61
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES O=C(C(c1cccs1)(c1cccs1)O)OC1CC2C3C(C(C1)[N+]2(C)C)O3
Isomeric SMILES O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3
InChI InChI=1S/C19H22NO4S2/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(21)19(22,14-5-3-7-25-14)15-6-4-8-26-15/h3-8,11-13,16-17,22H,9-10H2,1-2H3/q+1/t11?,12-,13+,16-,17+
InChI Key LERNTVKEWCAPOY-FPISHFTHSA-N
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
M4 receptor Hs Antagonist Antagonist 10.2 – 10.6 pKi - 4-5
pKi 10.2 – 10.6 [4-5]
M3 receptor Primary target of this compound Hs Antagonist Antagonist 9.5 – 11.1 pKi - 1-5
pKi 9.5 – 11.1 [1-5]
M2 receptor Hs Antagonist Antagonist 9.9 – 10.7 pKi - 1,3-5
pKi 9.9 – 10.7 [1,3-5]
M1 receptor Hs Antagonist Antagonist 9.6 – 10.7 pKi - 1,3-5
pKi 9.6 – 10.7 [1,3-5]
M5 receptor Hs Antagonist Antagonist 9.8 – 10.2 pKi - 4-5
pKi 9.8 – 10.2 [4-5]
Ligand mentioned in the following text fields