tiotropium [Ligand Id: 367] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL3305968
  • M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229]
There should be some charts here, you may need to enable JavaScript!
  • M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
There should be some charts here, you may need to enable JavaScript!
  • M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
There should be some charts here, you may need to enable JavaScript!
  • M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
There should be some charts here, you may need to enable JavaScript!
  • M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229]
GtoPdb - - 10.7 pKi - - - J Med Chem (2009) 52: 5076-92 [PMID:19653626];
Life Sci (1993) 52: 537-44 [PMID:8441333];
J Pharmacol Exp Ther (2012) 343: 520-8 [PMID:22854200];
Bioorg Med Chem Lett (2010) 20: 7429-34 [PMID:21036042]
M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
GtoPdb - - 10.7 pKi - - - J Med Chem (2009) 52: 5076-92 [PMID:19653626];
Life Sci (1993) 52: 537-44 [PMID:8441333];
J Pharmacol Exp Ther (2012) 343: 520-8 [PMID:22854200];
Bioorg Med Chem Lett (2010) 20: 7429-34 [PMID:21036042]
M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
GtoPdb - - 11.1 pKi - - - Br J Pharmacol (2006) 148: 927-37 [PMID:16847442];
J Med Chem (2009) 52: 5076-92 [PMID:19653626];
Life Sci (1993) 52: 537-44 [PMID:8441333];
J Pharmacol Exp Ther (2012) 343: 520-8 [PMID:22854200];
Bioorg Med Chem Lett (2010) 20: 7429-34 [PMID:21036042]
M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
GtoPdb - - 10.6 pKi - - - J Pharmacol Exp Ther (2012) 343: 520-8 [PMID:22854200];
Bioorg Med Chem Lett (2010) 20: 7429-34 [PMID:21036042]
M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912]
GtoPdb - - 10.2 pKi - - - J Pharmacol Exp Ther (2012) 343: 520-8 [PMID:22854200];
Bioorg Med Chem Lett (2010) 20: 7429-34 [PMID:21036042]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]