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TL1A   Click here for help

GtoPdb Ligand ID: 5071

Synonyms: Tumor necrosis factor ligand superfamily member 15, membrane form
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: TL1A occurs as both membrane‐bound and soluble forms. It principally functions as a negative modulator of epithelial cell proliferation.
Inhibiting the TL1A/death receptor 3 (TNFRSF25) pathway has been proposed as mechanism to treat inflammatory bowel disease [1]. In addition, TL1A has been associated with tumourigenesis and progression of some gastrointestinal malignancies [3,5,9], making it a target of interest for the development of novel anti-cancer drugs, and profibrotic processes.
TL1A is also an endogenous ligand for decoy receptor 3 (DcR3; TNFRSF6B).
Species: Human
Natural/Endogenous Targets
Target
death receptor 3
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
death receptor 3 Ligand is endogenous in the given species Hs None - - - -
⤷
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
duvakitug Peptide Hs Antibody Binding 10.4 pKd - 7
⤷ pKd 10.4 (Kd 4.1x10-11 M) [7]
Targets where the ligand is described in the comment field
Target Comment
decoy receptor 3 Decoy receptor for LIGHT (TNFSF14, O43557), TL1A (TNFSF15, O95150) and Fas ligand (FASLG, P48023).