TL1A

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Ligands
TL1A (Human)

GtoPdb Ligand ID: 5071

Synonyms: Tumor necrosis factor ligand superfamily member 15, membrane form

Compound class: Endogenous peptide in human, mouse or rat

Comment: TL1A occurs as both membrane‐bound and soluble forms. It principally functions as a negative modulator of epithelial cell proliferation. Inhibiting the TL1A/death receptor 3 (TNFRSF25) pathway has been proposed as mechanism to treat inflammatory bowel disease [1]. In addition, TL1A has been associated with tumourigenesis and progression of some gastrointestinal malignancies [3,5,7], making it a target of interest for the development of novel anti-cancer drugs.

Species: Human

References
1. Banfield C, Rudin D, Bhattacharya I, Goteti K, Li G, Hassan-Zahraee M, Brown LS, Hung KE, Pawlak S, Lepsy C. (2020) First-in-human, randomized dose-escalation study of the safety, tolerability, pharmacokinetics, pharmacodynamics and immunogenicity of PF-06480605 in healthy subjects. Br J Clin Pharmacol, 86 (4): 812-824. [PMID:31758576]
2. Danese S, Klopocka M, Scherl EJ, Romatowski J, Allegretti JR, Peeva E, Vincent MS, Schoenbeck U, Ye Z, Hassan-Zahraee M et al.. (2021) Anti-TL1A Antibody PF-06480605 Safety and Efficacy for Ulcerative Colitis: A Phase 2a Single-Arm Study. Clin Gastroenterol Hepatol, 19 (11): 2324-2332.e6. [PMID:34126262]
3. Gao Y, Wang Y, Wang X, Wang Y, Zhang X, Sun X. (2019) TNF-like ligand 1A is associated with progression and prognosis of human gastric cancer. Onco Targets Ther, 12: 7715-7723. [PMID:31571922]
4. Kakuta Y, Kinouchi Y, Negoro K, Takahashi S, Shimosegawa T. (2006) Association study of TNFSF15 polymorphisms in Japanese patients with inflammatory bowel disease. Gut, 55 (10): 1527-8. [PMID:16966713]
5. Lagou S, Grapsa D, Syrigos N, Bamias G. (2022) The Role of Decoy Receptor DcR3 in Gastrointestinal Malignancy. Cancer Diagn Progn, 2 (4): 411-421. [PMID:35813013]
6. Picornell Y, Mei L, Taylor K, Yang H, Targan SR, Rotter JI. (2007) TNFSF15 is an ethnic-specific IBD gene. Inflamm Bowel Dis, 13 (11): 1333-8. [PMID:17663424]
7. Zhang T, Ning WW, Zhang J, Xu FJ, Wang XQ, Li ZB, Xie M. (2022) Nonylphenol regulates TL1A through the AhR/HDAC2/HNF4α pathway in endothelial cells to promote the angiogenesis of colorectal cancer. Toxicol Appl Pharmacol, 436: 115854. [PMID:34974051]

References

1. Banfield C, Rudin D, Bhattacharya I, Goteti K, Li G, Hassan-Zahraee M, Brown LS, Hung KE, Pawlak S, Lepsy C. (2020)
First-in-human, randomized dose-escalation study of the safety, tolerability, pharmacokinetics, pharmacodynamics and immunogenicity of PF-06480605 in healthy subjects.
Br J Clin Pharmacol, 86 (4): 812-824. [PMID:31758576]

2. Danese S, Klopocka M, Scherl EJ, Romatowski J, Allegretti JR, Peeva E, Vincent MS, Schoenbeck U, Ye Z, Hassan-Zahraee M et al.. (2021)
Anti-TL1A Antibody PF-06480605 Safety and Efficacy for Ulcerative Colitis: A Phase 2a Single-Arm Study.
Clin Gastroenterol Hepatol, 19 (11): 2324-2332.e6. [PMID:34126262]

3. Gao Y, Wang Y, Wang X, Wang Y, Zhang X, Sun X. (2019)
TNF-like ligand 1A is associated with progression and prognosis of human gastric cancer.
Onco Targets Ther, 12: 7715-7723. [PMID:31571922]

4. Kakuta Y, Kinouchi Y, Negoro K, Takahashi S, Shimosegawa T. (2006)
Association study of TNFSF15 polymorphisms in Japanese patients with inflammatory bowel disease.
Gut, 55 (10): 1527-8. [PMID:16966713]

5. Lagou S, Grapsa D, Syrigos N, Bamias G. (2022)
The Role of Decoy Receptor DcR3 in Gastrointestinal Malignancy.
Cancer Diagn Progn, 2 (4): 411-421. [PMID:35813013]

6. Picornell Y, Mei L, Taylor K, Yang H, Targan SR, Rotter JI. (2007)
TNFSF15 is an ethnic-specific IBD gene.
Inflamm Bowel Dis, 13 (11): 1333-8. [PMID:17663424]

7. Zhang T, Ning WW, Zhang J, Xu FJ, Wang XQ, Li ZB, Xie M. (2022)
Nonylphenol regulates TL1A through the AhR/HDAC2/HNF4α pathway in endothelial cells to promote the angiogenesis of colorectal cancer.
Toxicol Appl Pharmacol, 436: 115854. [PMID:34974051]