Natural/Endogenous Targets
Target BAFF receptor B cell maturation antigen TACI

Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference TACI Hs None - - - - ⤷ BAFF receptor Hs None - - - - ⤷ B cell maturation antigen Hs None - - - - ⤷

Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference blisibimod Hs None Binding 11.4 pKd - 5 ⤷ pKd 11.4 (Kd 4x10-12 M) [5] Description: Binding to human AGP3 (=BAFF) atacicept Hs None Binding 9.9 – 10.1 pKd - 6 ⤷ pKd 9.9 – 10.1 (Kd 1.35x10-10 – 9x10-11 M) [6] Description: Competitive binding to [125I]BAFF.

Other ligands which bind to or alter the activity of this ligand
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Ligand Sp. Type Action Value Parameter Concentration range (M) Reference tibulizumab Hs Antibody Binding 10.2 pKd - 1 ⤷ pKd 10.2 (Kd 6x10-11 M) [1] tabalumab Hs Antibody Binding 8.0 pKd - 3 ⤷ pKd 8.0 (Kd 1x10-8 M) [3] belimumab Hs Antibody Binding 10.6 pEC50 - 2 ⤷ pEC50 10.6 (EC50 2.4x10-11 M) [2] Description: Binding affinity to immobilised BLyS telitacicept Hs Fusion protein Binding - - - 8 ⤷ [8]