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Target has curated data in GtoImmuPdb
Target id: 1885
Nomenclature: TACI
Systematic Nomenclature: TNFRSF13B
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 293 | 17p11.2 | TNFRSF13B | TNF receptor superfamily member 13B | |
Mouse | 1 | 249 | 11 B2 | Tnfrsf13b | tumor necrosis factor receptor superfamily, member 13b | |
Rat | - | - | Tnfrsf13b | TNF receptor superfamily member 13B |
Database Links | |
Alphafold | O14836 (Hs), Q9ET35 (Mm) |
Ensembl Gene | ENSG00000240505 (Hs), ENSMUSG00000010142 (Mm), ENSRNOG00000002304 (Rn) |
Entrez Gene | 23495 (Hs), 57916 (Mm), 691719 (Rn) |
Human Protein Atlas | ENSG00000240505 (Hs) |
KEGG Gene | hsa:23495 (Hs), mmu:57916 (Mm), rno:691719 (Rn) |
OMIM | 604907 (Hs) |
Pharos | O14836 (Hs) |
UniProtKB | O14836 (Hs), Q9ET35 (Mm) |
Wikipedia | TNFRSF13B (Hs) |
Natural/Endogenous Ligands |
APRIL {Sp: Human} |
BAFF {Sp: Human} |
Adaptor proteins (Human) |
TRAF2, TRAF5, TRAF6 |
Other Binding Ligands | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immunopharmacology Comments |
TACI is a lymphocyte-specific TNF superfamily receptor expressed on B cells. Endogenous ligands include APRIL, BAFF and CAML. Defects in the function of TACI can underlie immunodeficiencies and autoimmune diseases. TACI ligands are molecular targets of approved and investigational biologics that are intended to treat B cell-mediated immune system defects |
Immuno Process Associations | ||
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Clinically-Relevant Mutations and Pathophysiology | ||||||||||||||||||||
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1. Castigli E, Wilson SA, Garibyan L, Rachid R, Bonilla F, Schneider L, Geha RS. (2005) TACI is mutant in common variable immunodeficiency and IgA deficiency. Nat Genet, 37 (8): 829-34. [PMID:16007086]
2. Salzer U, Chapel HM, Webster AD, Pan-Hammarström Q, Schmitt-Graeff A, Schlesier M, Peter HH, Rockstroh JK, Schneider P, Schäffer AA et al.. (2005) Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans. Nat Genet, 37 (8): 820-8. [PMID:16007087]