TACI | Tumour necrosis factor (TNF) receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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TACI

  Target has curated data in GtoImmuPdb

Target id: 1885

Nomenclature: TACI

Systematic Nomenclature: TNFRSF13B

Family: Tumour necrosis factor (TNF) receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 293 17p11.2 TNFRSF13B TNF receptor superfamily member 13B
Mouse 1 249 Tnfrsf13b tumor necrosis factor receptor superfamily
Rat - - Tnfrsf13b TNF receptor superfamily member 13B
Previous and Unofficial Names
CD267 | tumor necrosis factor receptor superfamily, member 13B | Transmembrane activator and CAML interactor | tumor necrosis factor receptor superfamily member 13B | tumor necrosis factor receptor superfamily | tumor necrosis factor receptor superfamily, member 13b
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Natural/Endogenous Ligands
APRIL {Sp: Human}
BAFF {Sp: Human}
Adaptor proteins (Human)
TRAF2, TRAF5, TRAF6
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Parameter Reference
APRIL {Sp: Human} N/A - - -
BAFF {Sp: Human} Hs - - -
Immunopharmacology Comments
TACI is a lymphocyte-specific TNF superfamily receptor expressed on B cells. Endogenous ligands include APRIL, BAFF and CAML. Defects in the function of TACI can underlie immunodeficiencies and autoimmune diseases. A TACI-IgG Fc fusion protein named RC18 will be evaluated in Phase 3 clinical trials in patients with rheumatoId arthritis (NCT03016013) and neuromyelitis optica spectrum disorders (NCT03330418). Phase 2 study NCT02885610 will examine RC18 in systemic lupus erythematosus patients.
Immuno Process Associations
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 2 GO processes
GO:0030889 negative regulation of B cell proliferation IBA
click arrow to show/hide IEA associations
GO:0002250 adaptive immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:0001782 B cell homeostasis IBA
GO:0030889 negative regulation of B cell proliferation IBA
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes
GO:0002244 hematopoietic progenitor cell differentiation IBA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0030889 negative regulation of B cell proliferation IBA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002250 adaptive immune response IEA
Clinically-Relevant Mutations and Pathophysiology
Disease:  Common variable immunodeficiency
Description: CVID is a group of genetically heterogeneous primary immunodeficiencies. Whilst a small number of cases can be linked to deficiency in a single gene (see the OMIM links as examples), the cause is likely to be polygenic in the majority of cases. Symptoms vary between patients, but CVID is generally characterised by a failure to produce antibodies (hypogammaglobulinemia) and therefore susceptibility to recurrent infections and inflammation (including autoimmunity).
Disease Ontology: DOID:12177
OMIM: 613495, 607594, 606453, 240500, 613493
Orphanet: ORPHA1572
Role: 
Comments: 
References:  1-2

References

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1. Castigli E, Wilson SA, Garibyan L, Rachid R, Bonilla F, Schneider L, Geha RS. (2005) TACI is mutant in common variable immunodeficiency and IgA deficiency. Nat. Genet., 37 (8): 829-34. [PMID:16007086]

2. Salzer U, Chapel HM, Webster AD, Pan-Hammarström Q, Schmitt-Graeff A, Schlesier M, Peter HH, Rockstroh JK, Schneider P, Schäffer AA et al.. (2005) Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans. Nat. Genet., 37 (8): 820-8. [PMID:16007087]

Contributors

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How to cite this page

David MacEwan.
Tumour necrosis factor (TNF) receptor family: TACI. Last modified on 20/03/2018. Accessed on 26/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1885.