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ChEMBL ligand: CHEMBL1270399 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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calcium/calmodulin dependent protein kinase IV/CaM kinase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2494] [GtoPdb: 1955] [UniProtKB: Q16566] | ||||||||
ChEMBL | Inhibition of Camk4 | B | 8 | pIC50 | >10 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6739-6743 [PMID:20855207] |
casein kinase 1 delta/Casein kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730] | ||||||||
ChEMBL | Inhibition of CSNK1d | B | 8 | pIC50 | >10 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6739-6743 [PMID:20855207] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
ChEMBL | Inhibition of CDK2 | B | 8 | pIC50 | >10 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6739-6743 [PMID:20855207] |
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
ChEMBL | Inhibition of EGFR | B | 8 | pIC50 | >10 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6739-6743 [PMID:20855207] |
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
ChEMBL | Inhibition of cMET | B | 8 | pIC50 | >10 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6739-6743 [PMID:20855207] |
inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920] | ||||||||
ChEMBL | Inhibition of IKK-beta | B | 8 | pIC50 | >10 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6739-6743 [PMID:20855207] |
interleukin 1 receptor associated kinase 4/Interleukin-1 receptor-associated kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3778] [GtoPdb: 2045] [UniProtKB: Q9NWZ3] | ||||||||
ChEMBL | Inhibition of IRK4 | B | 5.74 | pIC50 | 1800 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6739-6743 [PMID:20855207] |
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
ChEMBL | Inhibition of ERK2 | B | 8 | pIC50 | >10 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6739-6743 [PMID:20855207] |
protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252] | ||||||||
ChEMBL | Inhibition of PKCalpha | B | 8 | pIC50 | >10 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6739-6743 [PMID:20855207] |
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116] | ||||||||
ChEMBL | Inhibition of ROCK2 | B | 8 | pIC50 | >10 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6739-6743 [PMID:20855207] |
ribosomal protein S6 kinase A3/Ribosomal protein S6 kinase alpha 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2345] [GtoPdb: 1528] [UniProtKB: P51812] | ||||||||
ChEMBL | Inhibition of RSK2 | B | 6.48 | pIC50 | 330 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6739-6743 [PMID:20855207] |
AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
ChEMBL | Inhibition of AKT1 | B | 8 | pIC50 | >10 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6739-6743 [PMID:20855207] |
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] | ||||||||
ChEMBL | Inhibition of Aurora A | B | 8.4 | pIC50 | <=4 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6739-6743 [PMID:20855207] |
GtoPdb | - | - | 8.4 | pIC50 | <4 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6739-43 [PMID:20855207] |
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4] | ||||||||
ChEMBL | Inhibition of Aurora B | B | 7.89 | pIC50 | <=13 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6739-6743 [PMID:20855207] |
GtoPdb | - | - | 7.89 | pIC50 | <13 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6739-43 [PMID:20855207] |
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757] | ||||||||
GtoPdb | - | - | 6.85 | pIC50 | 140 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6739-43 [PMID:20855207] |
ChEMBL | Inhibition of CHK1 | B | 6.85 | pIC50 | 140 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6739-6743 [PMID:20855207] |
polo like kinase 3/Serine/threonine-protein kinase PLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4897] [GtoPdb: 2170] [UniProtKB: Q9H4B4] | ||||||||
ChEMBL | Inhibition of PLK3 | B | 8 | pIC50 | >10 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6739-6743 [PMID:20855207] |
testis specific serine kinase 2/Testis-specific serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6014] [GtoPdb: 2258] [UniProtKB: Q96PF2] | ||||||||
ChEMBL | Inhibition of TSSK2 | B | 8 | pIC50 | >10 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6739-6743 [PMID:20855207] |
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
ChEMBL | Inhibition of JAK2 | B | 8 | pIC50 | >10 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6739-6743 [PMID:20855207] |
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
ChEMBL | Inhibition of LCK | B | 6.29 | pIC50 | 510 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6739-6743 [PMID:20855207] |
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
ChEMBL | Inhibition of VEGFR2 | B | 6.15 | pIC50 | 710 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6739-6743 [PMID:20855207] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]