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ChEMBL ligand: CHEMBL2409707 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
ChEMBL | Inhibition of human ERG channel by electrophysiological assay | B | 4.4 | pIC50 | 40000 | nM | IC50 | Bioorg. Med. Chem. Lett. (2013) 23: 4705-4712 [PMID:23810497] |
MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452] | ||||||||
GtoPdb | - | - | 8.3 | pIC50 | 5 | nM | IC50 | AZD6605 Matrix metallopeptidase 13 (MMP13) inhibitor.. MRC/AstraZeneca: Mechanisms of Disease Call |
ChEMBL | Inhibition of human recombinant MMP-13 using Mca-Pro-beta-cyclohexyl-Ala-Gly-Nva-His-Ala-Dap(Dnp)-NH2 as substrate after 20 hrs by fluorescence assay | B | 8.33 | pIC50 | 4.7 | nM | IC50 | Bioorg. Med. Chem. Lett. (2013) 23: 4705-4712 [PMID:23810497] |
MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281] | ||||||||
ChEMBL | Inhibition of human recombinant MMP-14 using Mca-Pro-Leu-Ala-Nva-Dpa-Ala-Arg-NH2 as substrate after 20 hrs by fluorescence assay | B | 5.65 | pIC50 | 2220 | nM | IC50 | Bioorg. Med. Chem. Lett. (2013) 23: 4705-4712 [PMID:23810497] |
MMP2 in Human [GtoPdb: 1629] [UniProtKB: P08253] | ||||||||
GtoPdb | - | - | 8.52 | pIC50 | 3 | nM | IC50 | AZD6605 Matrix metallopeptidase 13 (MMP13) inhibitor.. MRC/AstraZeneca: Mechanisms of Disease Call |
MMP9 in Human [GtoPdb: 1633] [UniProtKB: P14780] | ||||||||
GtoPdb | - | - | 8.7 | pIC50 | 2 | nM | IC50 | AZD6605 Matrix metallopeptidase 13 (MMP13) inhibitor.. MRC/AstraZeneca: Mechanisms of Disease Call |
MMP12 in Human [GtoPdb: 1636] [UniProtKB: P39900] | ||||||||
GtoPdb | - | - | 9.22 | pIC50 | 0.6 | nM | IC50 | AZD6605 Matrix metallopeptidase 13 (MMP13) inhibitor.. MRC/AstraZeneca: Mechanisms of Disease Call |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]