AZD6605 [Ligand Id: 7823] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2409707 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG channel by electrophysiological assay | B | 4.4 | pIC50 | 40000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4705-4712 [PMID:23810497] |
| MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452] | ||||||||
| GtoPdb | - | - | 8.3 | pIC50 | 5 | nM | IC50 | AZD6605 Matrix metallopeptidase 13 (MMP13) inhibitor.. MRC/AstraZeneca: Mechanisms of Disease Call |
| ChEMBL | Inhibition of human recombinant MMP-13 using Mca-Pro-beta-cyclohexyl-Ala-Gly-Nva-His-Ala-Dap(Dnp)-NH2 as substrate after 20 hrs by fluorescence assay | B | 8.33 | pIC50 | 4.7 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4705-4712 [PMID:23810497] |
| MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281] | ||||||||
| ChEMBL | Inhibition of human recombinant MMP-14 using Mca-Pro-Leu-Ala-Nva-Dpa-Ala-Arg-NH2 as substrate after 20 hrs by fluorescence assay | B | 5.65 | pIC50 | 2220 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4705-4712 [PMID:23810497] |
| MMP2 in Human [GtoPdb: 1629] [UniProtKB: P08253] | ||||||||
| GtoPdb | - | - | 8.52 | pIC50 | 3 | nM | IC50 | AZD6605 Matrix metallopeptidase 13 (MMP13) inhibitor.. MRC/AstraZeneca: Mechanisms of Disease Call |
| MMP9 in Human [GtoPdb: 1633] [UniProtKB: P14780] | ||||||||
| GtoPdb | - | - | 8.7 | pIC50 | 2 | nM | IC50 | AZD6605 Matrix metallopeptidase 13 (MMP13) inhibitor.. MRC/AstraZeneca: Mechanisms of Disease Call |
| MMP12 in Human [GtoPdb: 1636] [UniProtKB: P39900] | ||||||||
| GtoPdb | - | - | 9.22 | pIC50 | 0.6 | nM | IC50 | AZD6605 Matrix metallopeptidase 13 (MMP13) inhibitor.. MRC/AstraZeneca: Mechanisms of Disease Call |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
