AZD6605 [Ligand Id: 7823] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2409707 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG channel by electrophysiological assay | B | 4.4 | pIC50 | 40000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4705-4712 [PMID:23810497] |
| MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452] | ||||||||
| GtoPdb | - | - | 8.3 | pIC50 | 5 | nM | IC50 | AZD6605 Matrix metallopeptidase 13 (MMP13) inhibitor.. MRC/AstraZeneca: Mechanisms of Disease Call |
| ChEMBL | Inhibition of human recombinant MMP-13 using Mca-Pro-beta-cyclohexyl-Ala-Gly-Nva-His-Ala-Dap(Dnp)-NH2 as substrate after 20 hrs by fluorescence assay | B | 8.33 | pIC50 | 4.7 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4705-4712 [PMID:23810497] |
| MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281] | ||||||||
| ChEMBL | Inhibition of human recombinant MMP-14 using Mca-Pro-Leu-Ala-Nva-Dpa-Ala-Arg-NH2 as substrate after 20 hrs by fluorescence assay | B | 5.65 | pIC50 | 2220 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4705-4712 [PMID:23810497] |
| MMP2 in Human [GtoPdb: 1629] [UniProtKB: P08253] | ||||||||
| GtoPdb | - | - | 8.52 | pIC50 | 3 | nM | IC50 | AZD6605 Matrix metallopeptidase 13 (MMP13) inhibitor.. MRC/AstraZeneca: Mechanisms of Disease Call |
| MMP9 in Human [GtoPdb: 1633] [UniProtKB: P14780] | ||||||||
| GtoPdb | - | - | 8.7 | pIC50 | 2 | nM | IC50 | AZD6605 Matrix metallopeptidase 13 (MMP13) inhibitor.. MRC/AstraZeneca: Mechanisms of Disease Call |
| MMP12 in Human [GtoPdb: 1636] [UniProtKB: P39900] | ||||||||
| GtoPdb | - | - | 9.22 | pIC50 | 0.6 | nM | IC50 | AZD6605 Matrix metallopeptidase 13 (MMP13) inhibitor.. MRC/AstraZeneca: Mechanisms of Disease Call |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
