Top ▲
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 470 | 11q22.2 | MMP12 | matrix metallopeptidase 12 | |
Mouse | - | 473 | 9 2.46 cM | Mmp12 | matrix metallopeptidase 12 | |
Rat | - | 465 | 8q11 | Mmp12 | matrix metallopeptidase 12 |
Previous and Unofficial Names |
Mme | Mmel | Macrophage metalloelastase | matrix metallopeptidase 12 (macrophage elastase) |
Database Links | |
Specialist databases | |
MEROPS | M10.009 (Hs) |
Other databases | |
Alphafold | P39900 (Hs), P34960 (Mm), Q63341 (Rn) |
BRENDA | 3.4.24.65 |
CATH/Gene3D | 3.40.390.10, 2.110.10.10 |
ChEMBL Target | CHEMBL4393 (Hs), CHEMBL2594 (Mm), CHEMBL5506 (Rn) |
DrugBank Target | P39900 (Hs) |
Ensembl Gene | ENSG00000262406 (Hs), ENSMUSG00000049723 (Mm), ENSRNOG00000030187 (Rn) |
Entrez Gene | 4321 (Hs), 17381 (Mm), 117033 (Rn) |
Human Protein Atlas | ENSG00000262406 (Hs) |
KEGG Enzyme | 3.4.24.65 |
KEGG Gene | hsa:4321 (Hs), mmu:17381 (Mm), rno:117033 (Rn) |
OMIM | 601046 (Hs) |
Pharos | P39900 (Hs) |
RefSeq Nucleotide | NM_002426 (Hs), NM_008605 (Mm), NM_053963 (Rn) |
RefSeq Protein | NP_002417 (Hs), NP_032631 (Mm), NP_446415 (Rn) |
SynPHARM | 80658 (in complex with RXP470.1) |
UniProtKB | P39900 (Hs), P34960 (Mm), Q63341 (Rn) |
Wikipedia | MMP12 (Hs) |
Enzyme Reaction | ||||
|
Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
Immunopharmacology Comments |
MMP12 is included in GtoImmuPdb based on its reported involvement in asthma and potential as a asthma therapeutic target. |
Immuno Process Associations | ||
|
||
|
||
|
Immuno Disease Associations | ||||||||||
|
1. AstraZeneca. AZD1236. Accessed on 31/10/2014. Modified on 31/10/2014. Open Innovation, http://openinnovation.astrazeneca.com/what-we-offer/compound/azd1236/
2. Cobos-Correa A, Stein F, Schultz C. (2012) Target-Activated Prodrugs (TAPs) for the Autoregulated Inhibition of MMP12. ACS Med Chem Lett, 3 (8): 653-7. [PMID:24900526]
3. Czarny B, Stura EA, Devel L, Vera L, Cassar-Lajeunesse E, Beau F, Calderone V, Fragai M, Luchinat C, Dive V. (2013) Molecular determinants of a selective matrix metalloprotease-12 inhibitor: insights from crystallography and thermodynamic studies. J Med Chem, 56 (3): 1149-59. [PMID:23343195]
4. Ma D, Wu W, Yang G, Li J, Li J, Ye Q. (2004) Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors. Bioorg Med Chem Lett, 14 (1): 47-50. [PMID:14684295]
5. MRC. AZD6605 Matrix metallopeptidase 13 (MMP13) inhibitor. Accessed on 28/10/2014. Modified on 28/10/2014. MRC/AstraZeneca: Mechanisms of Disease Call, http://webarchive.nationalarchives.gov.uk/20120104105854/http://www.mrc.ac.uk/consumption/groups/public/documents/content/mrc008371.pdf
6. Mukhopadhyay S, Sypek J, Tavendale R, Gartner U, Winter J, Li W, Page K, Fleming M, Brady J, O'Toole M et al.. (2010) Matrix metalloproteinase-12 is a therapeutic target for asthma in children and young adults. J Allergy Clin Immunol, 126 (1): 70-6.e16. [PMID:20546881]
7. Takeuchi T, Hayashi M, Tamita T, Nomura Y, Kojima N, Mitani A, Takeda T, Hitaka K, Kato Y, Kamitani M et al.. (2022) Discovery of Aryloxyphenyl-Heptapeptide Hybrids as Potent and Selective Matrix Metalloproteinase-2 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis. J Med Chem, 65 (12): 8493-8510. [PMID:35687819]
8. Wu Y, Li J, Wu J, Morgan P, Xu X, Rancati F, Vallese S, Raveglia L, Hotchandani R, Fuller N et al.. (2012) Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD). Bioorg Med Chem Lett, 22 (1): 138-43. [PMID:22153340]
M10: Matrix metallopeptidase: MMP12. Last modified on 12/07/2022. Accessed on 09/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1636.