CH7057288 [Ligand Id: 12237] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4457566 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629] | ||||||||
| ChEMBL | Inhibition of human TrkA G595R mutant expressed in mouse NIH/3T3 cells by HTRF assay | B | 7.08 | pIC50 | 83 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 126624-126624 [PMID:31444087] |
| ChEMBL | Inhibition of human wild type TrkA kinase domain expressed in mouse NIH/3T3 cells by HTRF assay | B | 8.82 | pIC50 | 1.5 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 126624-126624 [PMID:31444087] |
| GtoPdb | - | - | 8.92 | pIC50 | 1.2 | nM | IC50 | J Med Chem (2022) 65: 12427-12444 [PMID:36066182] |
| ChEMBL | Inhibition of human TrkA G667C mutant expressed in mouse NIH/3T3 cells by HTRF assay | B | 9.17 | pIC50 | 0.68 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 126624-126624 [PMID:31444087] |
| neurotrophic receptor tyrosine kinase 2 in Human [GtoPdb: 1818] [UniProtKB: Q16620] | ||||||||
| GtoPdb | - | - | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (2022) 65: 12427-12444 [PMID:36066182] |
| neurotrophic receptor tyrosine kinase 3 in Human [GtoPdb: 1819] [UniProtKB: Q16288] | ||||||||
| GtoPdb | - | - | 8.55 | pIC50 | 2.8 | nM | IC50 | J Med Chem (2022) 65: 12427-12444 [PMID:36066182] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
