Ion channel subunits
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| Calcium- and sodium-activated potassium channels (KCa, KNa) | ||||||
| Family name | Physiological ion | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| Calcium- and sodium-activated potassium channels (KCa, KNa) | K+ | KCa1.1 |
KCNMA1 |
Kcnma1 |
Kcnma1 |
|
| Calcium- and sodium-activated potassium channels (KCa, KNa) | K+ | KCa2.1 |
KCNN1 |
Kcnn1 |
Kcnn1 |
|
| Calcium- and sodium-activated potassium channels (KCa, KNa) | K+ | KCa2.2 |
KCNN2 |
Kcnn2 |
Kcnn2 |
|
| Calcium- and sodium-activated potassium channels (KCa, KNa) | K+ | KCa2.3 |
KCNN3 |
Kcnn3 |
Kcnn3 |
|
| Calcium- and sodium-activated potassium channels (KCa, KNa) | K+ | KCa3.1 |
KCNN4 |
Kcnn4 |
Kcnn4 |
|
| Calcium- and sodium-activated potassium channels (KCa, KNa) | K+ | KNa1.1 |
KCNT1 |
Kcnt1 |
Kcnt1 |
|
| Calcium- and sodium-activated potassium channels (KCa, KNa) | K+ | KNa1.2 |
KCNT2 |
Kcnt2 |
Kcnt2 |
|
| Calcium- and sodium-activated potassium channels (KCa, KNa) | K+ | KCa5.1 |
KCNU1 |
Kcnu1 |
Kcnu1 |
|
| CatSper and Two-Pore channels (TPC) | ||||||
| Family name | Physiological ion | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| CatSper and Two-Pore channels (TPC) | Ca2+ | CatSper1 |
CATSPER1 |
Catsper1 |
Catsper1 |
|
| CatSper and Two-Pore channels (TPC) | Ca2+ | CatSper2 |
CATSPER2 |
Catsper2 |
Catsper2 |
|
| CatSper and Two-Pore channels (TPC) | Ca2+ | CatSper3 |
CATSPER3 |
Catsper3 |
Catsper3 |
|
| CatSper and Two-Pore channels (TPC) | Ca2+ | CatSper4 |
CATSPER4 |
Catsper4 |
Catsper4 |
|
| CatSper and Two-Pore channels (TPC) | Ca2+ | TPC1 |
TPCN1 |
Tpcn1 |
Tpcn1 |
|
| CatSper and Two-Pore channels (TPC) | Ca2+ | TPC2 |
TPCN2 |
Tpcn2 |
Tpcn2 |
|
| Cyclic nucleotide-regulated channels (CNG) | ||||||
| Family name | Physiological ion | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| Cyclic nucleotide-regulated channels (CNG) | See comments below | CNGA1 |
CNGA1 |
Cnga1 |
Cnga1 |
|
| Cyclic nucleotide-regulated channels (CNG) | See comments below | CNGA2 |
CNGA2 |
Cnga2 |
Cnga2 |
|
| Cyclic nucleotide-regulated channels (CNG) | See comments below | CNGA3 |
CNGA3 |
Cnga3 |
Cnga3 |
|
| Cyclic nucleotide-regulated channels (CNG) | See comments below | CNGA4 |
CNGA4 |
Cnga4 |
Cnga4 |
|
| Cyclic nucleotide-regulated channels (CNG) | See comments below | CNGB1 |
CNGB1 |
Cngb1 |
Cngb1 |
|
| Cyclic nucleotide-regulated channels (CNG) | See comments below | CNGB3 |
CNGB3 |
Cngb3 |
Cngb3 |
|
| Cyclic nucleotide-regulated channels (CNG) | See comments below | HCN1 |
HCN1 |
Hcn1 |
Hcn1 |
|
| Cyclic nucleotide-regulated channels (CNG) | See comments below | HCN2 |
HCN2 |
Hcn2 |
Hcn2 |
|
| Cyclic nucleotide-regulated channels (CNG) | See comments below | HCN3 |
HCN3 |
Hcn3 |
Hcn3 |
|
| Cyclic nucleotide-regulated channels (CNG) | See comments below | HCN4 |
HCN4 |
Hcn4 |
Hcn4 |
|
| Comments: Most of these channels are permeable to sodium, potassium and calcium ions, however the main physiological ion has yet to be definitively established. | ||||||
| Inwardly rectifying potassium channels (KIR) | ||||||
| Family name | Physiological ion | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| Inwardly rectifying potassium channels (KIR) | K+ | Kir1.1 |
KCNJ1 |
Kcnj1 |
Kcnj1 |
|
| Inwardly rectifying potassium channels (KIR) | K+ | Kir2.1 |
KCNJ2 |
Kcnj2 |
Kcnj2 |
|
| Inwardly rectifying potassium channels (KIR) | K+ | Kir2.2 |
KCNJ12 |
Kcnj12 |
Kcnj12 |
|
| Inwardly rectifying potassium channels (KIR) | K+ | Kir2.3 |
KCNJ4 |
Kcnj4 |
Kcnj4 |
|
| Inwardly rectifying potassium channels (KIR) | K+ | Kir2.4 |
KCNJ14 |
Kcnj14 |
Kcnj14 |
|
| Inwardly rectifying potassium channels (KIR) | K+ | Kir3.1 |
KCNJ3 |
Kcnj3 |
Kcnj3 |
|
| Inwardly rectifying potassium channels (KIR) | K+ | Kir3.2 |
KCNJ6 |
Kcnj6 |
Kcnj6 |
|
| Inwardly rectifying potassium channels (KIR) | K+ | Kir3.3 |
KCNJ9 |
Kcnj9 |
Kcnj9 |
|
| Inwardly rectifying potassium channels (KIR) | K+ | Kir3.4 |
KCNJ5 |
Kcnj5 |
Kcnj5 |
|
| Inwardly rectifying potassium channels (KIR) | K+ | Kir4.1 |
KCNJ10 |
Kcnj10 |
Kcnj10 |
|
| Inwardly rectifying potassium channels (KIR) | K+ | Kir4.2 |
KCNJ15 |
Kcnj15 |
Kcnj15 |
|
| Inwardly rectifying potassium channels (KIR) | K+ | Kir5.1 |
KCNJ16 |
Kcnj16 |
Kcnj16 |
|
| Inwardly rectifying potassium channels (KIR) | K+ | Kir6.1 |
KCNJ8 |
Kcnj8 |
Kcnj8 |
|
| Inwardly rectifying potassium channels (KIR) | K+ | Kir6.2 |
KCNJ11 |
Kcnj11 |
Kcnj11 |
|
| Inwardly rectifying potassium channels (KIR) | K+ | Kir7.1 |
KCNJ13 |
Kcnj13 |
Kcnj13 |
|
| Ryanodine receptors (RyR) | ||||||
| Family name | Physiological ion | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| Ryanodine receptors (RyR) | RyR1 |
RYR1 |
Ryr1 |
Ryr1 |
||
| Ryanodine receptors (RyR) | RyR2 |
RYR2 |
Ryr2 |
Ryr2 |
||
| Ryanodine receptors (RyR) | RyR3 |
RYR3 |
Ryr3 |
Ryr3 |
||
| Transient Receptor Potential channels (TRP) | ||||||
| Family name | Physiological ion | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| Transient Receptor Potential channels (TRP) | See comments below | TRPA1 |
TRPA1 |
Trpa1 |
Trpa1 |
|
| Transient Receptor Potential channels (TRP) | See comments below | TRPC1 |
TRPC1 |
Trpc1 |
Trpc1 |
|
| Transient Receptor Potential channels (TRP) | See comments below | TRPC2 |
TRPC2 |
Trpc2 |
Trpc2 |
|
| Transient Receptor Potential channels (TRP) | See comments below | TRPC3 |
TRPC3 |
Trpc3 |
Trpc3 |
|
| Transient Receptor Potential channels (TRP) | See comments below | TRPC4 |
TRPC4 |
Trpc4 |
Trpc4 |
|
| Transient Receptor Potential channels (TRP) | See comments below | TRPC5 |
TRPC5 |
Trpc5 |
Trpc5 |
|
| Transient Receptor Potential channels (TRP) | See comments below | TRPC6 |
TRPC6 |
Trpc6 |
Trpc6 |
|
| Transient Receptor Potential channels (TRP) | See comments below | TRPC7 |
TRPC7 |
Trpc7 |
Trpc7 |
|
| Transient Receptor Potential channels (TRP) | See comments below | TRPM1 |
TRPM1 |
Trpm1 |
Trpm1 |
|
| Transient Receptor Potential channels (TRP) | See comments below | TRPM2 |
TRPM2 |
Trpm2 |
Trpm2 |
|
| Transient Receptor Potential channels (TRP) | See comments below | TRPM3 |
TRPM3 |
Trpm3 |
Trpm3 |
|
| Transient Receptor Potential channels (TRP) | See comments below | TRPM4 |
TRPM4 |
Trpm4 |
Trpm4 |
|
| Transient Receptor Potential channels (TRP) | See comments below | TRPM5 |
TRPM5 |
Trpm5 |
Trpm5 |
|
| Transient Receptor Potential channels (TRP) | See comments below | TRPM6 |
TRPM6 |
Trpm6 |
Trpm6 |
|
| Transient Receptor Potential channels (TRP) | See comments below | TRPM7 |
TRPM7 |
Trpm7 |
Trpm7 |
|
| Transient Receptor Potential channels (TRP) | See comments below | TRPM8 |
TRPM8 |
Trpm8 |
Trpm8 |
|
| Transient Receptor Potential channels (TRP) | See comments below | TRPML1 |
MCOLN1 |
Mcoln1 |
Mcoln1 |
|
| Transient Receptor Potential channels (TRP) | See comments below | TRPML2 |
MCOLN2 |
Mcoln2 |
Mcoln2 |
|
| Transient Receptor Potential channels (TRP) | See comments below | TRPML3 |
MCOLN3 |
Mcoln3 |
Mcoln3 |
|
| Transient Receptor Potential channels (TRP) | See comments below | TRPP1 |
PKD2 |
Pkd2 |
Pkd2 |
|
| Transient Receptor Potential channels (TRP) | See comments below | TRPP2 |
PKD2L1 |
Pkd2l1 |
Pkd2l1 |
|
| Transient Receptor Potential channels (TRP) | See comments below | TRPP3 |
PKD2L2 |
Pkd2l2 |
Pkd2l2 |
|
| Transient Receptor Potential channels (TRP) | See comments below | TRPV1 |
TRPV1 |
Trpv1 |
Trpv1 |
|
| Transient Receptor Potential channels (TRP) | TRPV2 |
TRPV2 |
Trpv2 |
Trpv2 |
||
| Transient Receptor Potential channels (TRP) | See comments below | TRPV3 |
TRPV3 |
Trpv3 |
Trpv3 |
|
| Transient Receptor Potential channels (TRP) | See comments below | TRPV4 |
TRPV4 |
Trpv4 |
Trpv4 |
|
| Transient Receptor Potential channels (TRP) | See comments below | TRPV5 |
TRPV5 |
Trpv5 |
Trpv5 |
|
| Transient Receptor Potential channels (TRP) | See comments below | TRPV6 |
TRPV6 |
Trpv6 |
Trpv6 |
|
| Comments: Most of these channels are permeable to sodium, potassium and calcium ions, however the main physiological ion has yet to be definitively established. | ||||||
| Two-pore domain potassium channels (K2P) | ||||||
| Family name | Physiological ion | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| Two-pore domain potassium channels (K2P) | K+ | K2P1.1 |
KCNK1 |
Kcnk1 |
Kcnk1 |
|
| Two-pore domain potassium channels (K2P) | K+ | K2P2.1 |
KCNK2 |
Kcnk2 |
Kcnk2 |
|
| Two-pore domain potassium channels (K2P) | K+ | K2P3.1 |
KCNK3 |
Kcnk3 |
Kcnk3 |
|
| Two-pore domain potassium channels (K2P) | K+ | K2P4.1 |
KCNK4 |
Kcnk4 |
Kcnk4 |
|
| Two-pore domain potassium channels (K2P) | K+ | K2P5.1 |
KCNK5 |
Kcnk5 |
Kcnk5 |
|
| Two-pore domain potassium channels (K2P) | K+ | K2P6.1 |
KCNK6 |
Kcnk6 |
Kcnk6 |
|
| Two-pore domain potassium channels (K2P) | K+ | K2P7.1 |
KCNK7 |
Kcnk7 |
Kcnk7 |
|
| Two-pore domain potassium channels (K2P) | K+ | K2P9.1 |
KCNK9 |
Kcnk9 |
Kcnk9 |
|
| Two-pore domain potassium channels (K2P) | K+ | K2P10.1 |
KCNK10 |
Kcnk10 |
Kcnk10 |
|
| Two-pore domain potassium channels (K2P) | K+ | K2P12.1 |
KCNK12 |
Kcnk12 |
Kcnk12 |
|
| Two-pore domain potassium channels (K2P) | K+ | K2P13.1 |
KCNK13 |
Kcnk13 |
Kcnk13 |
|
| Two-pore domain potassium channels (K2P) | K+ | K2P15.1 |
KCNK15 |
Kcnk15 |
Kcnk15 |
|
| Two-pore domain potassium channels (K2P) | K+ | K2P16.1 |
KCNK16 |
Kcnk16 |
Kcnk16 |
|
| Two-pore domain potassium channels (K2P) | K+ | K2P17.1 |
KCNK17 |
|||
| Two-pore domain potassium channels (K2P) | K+ | K2P18.1 |
KCNK18 |
Kcnk18 |
Kcnk18 |
|
| Voltage-gated calcium channels (CaV) | ||||||
| Family name | Physiological ion | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| Voltage-gated calcium channels (CaV) | Ca2+ | Cav1.1 |
CACNA1S |
Cacna1s |
Cacna1s |
|
| Voltage-gated calcium channels (CaV) | Ca2+ | Cav1.2 |
CACNA1C |
Cacna1c |
Cacna1c |
|
| Voltage-gated calcium channels (CaV) | Ca2+ | Cav1.3 |
CACNA1D |
Cacna1d |
Cacna1d |
|
| Voltage-gated calcium channels (CaV) | Ca2+ | Cav1.4 |
CACNA1F |
Cacna1f |
Cacna1f |
|
| Voltage-gated calcium channels (CaV) | Ca2+ | Cav2.1 |
CACNA1A |
Cacna1a |
Cacna1a |
|
| Voltage-gated calcium channels (CaV) | Ca2+ | Cav2.2 |
CACNA1B |
Cacna1b |
Cacna1b |
|
| Voltage-gated calcium channels (CaV) | Ca2+ | Cav2.3 |
CACNA1E |
Cacna1e |
Cacna1e |
|
| Voltage-gated calcium channels (CaV) | Ca2+ | Cav3.1 |
CACNA1G |
Cacna1g |
Cacna1g |
|
| Voltage-gated calcium channels (CaV) | Ca2+ | Cav3.2 |
CACNA1H |
Cacna1h |
Cacna1h |
|
| Voltage-gated calcium channels (CaV) | Ca2+ | Cav3.3 |
CACNA1I |
Cacna1i |
Cacna1i |
|
| Voltage-gated potassium channels (Kv) | ||||||
| Family name | Physiological ion | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| Voltage-gated potassium channels (Kv) | K+ | Kv1.1 |
KCNA1 |
Kcna1 |
Kcna1 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv1.2 |
KCNA2 |
Kcna2 |
Kcna2 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv1.3 |
KCNA3 |
Kcna3 |
Kcna3 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv1.4 |
KCNA4 |
Kcna4 |
Kcna4 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv1.5 |
KCNA5 |
Kcna5 |
Kcna5 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv1.6 |
KCNA6 |
Kcna6 |
Kcna6 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv1.7 |
KCNA7 |
Kcna7 |
Kcna7 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv1.8 |
KCNA10 |
Kcna10 |
Kcna10 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv2.1 |
KCNB1 |
Kcnb1 |
Kcnb1 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv2.2 |
KCNB2 |
Kcnb2 |
Kcnb2 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv3.1 |
KCNC1 |
Kcnc1 |
Kcnc1 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv3.2 |
KCNC2 |
Kcnc2 |
Kcnc2 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv3.3 |
KCNC3 |
Kcnc3 |
Kcnc3 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv3.4 |
KCNC4 |
Kcnc4 |
Kcnc4 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv4.1 |
KCND1 |
Kcnd1 |
Kcnd1 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv4.2 |
KCND2 |
Kcnd2 |
Kcnd2 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv4.3 |
KCND3 |
Kcnd3 |
Kcnd3 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv5.1 |
KCNF1 |
Kcnf1 |
Kcnf1 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv6.1 |
KCNG1 |
Kcng1 |
Kcng1 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv6.2 |
KCNG2 |
Kcng2 |
Kcng2 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv6.3 |
KCNG3 |
Kcng3 |
Kcng3 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv6.4 |
KCNG4 |
Kcng4 |
Kcng4 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv7.1 |
KCNQ1 |
Kcnq1 |
Kcnq1 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv7.2 |
KCNQ2 |
Kcnq2 |
Kcnq2 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv7.3 |
KCNQ3 |
Kcnq3 |
Kcnq3 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv7.4 |
KCNQ4 |
Kcnq4 |
Kcnq4 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv7.5 |
KCNQ5 |
Kcnq5 |
Kcnq5 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv8.1 |
KCNV1 |
Kcnv1 |
Kcnv1 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv8.2 |
KCNV2 |
Kcnv2 |
Kcnv2 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv9.1 |
KCNS1 |
Kcns1 |
Kcns1 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv9.2 |
KCNS2 |
Kcns2 |
Kcns2 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv9.3 |
KCNS3 |
Kcns3 |
Kcns3 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv10.1 |
KCNH1 |
Kcnh1 |
Kcnh1 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv10.2 |
KCNH5 |
Kcnh5 |
Kcnh5 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv11.1 |
KCNH2 |
Kcnh2 |
Kcnh2 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv11.2 |
KCNH6 |
Kcnh6 |
Kcnh6 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv11.3 |
KCNH7 |
Kcnh7 |
Kcnh7 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv12.1 |
KCNH8 |
Kcnh8 |
Kcnh8 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv12.2 |
KCNH3 |
Kcnh3 |
Kcnh3 |
|
| Voltage-gated potassium channels (Kv) | K+ | Kv12.3 |
KCNH4 |
Kcnh4 |
Kcnh4 |
|
| Voltage-gated proton channel (Hv1) | ||||||
| Family name | Physiological ion | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| Voltage-gated proton channel (Hv1) | H+ | Hv1 |
HVCN1 |
Hvcn1 |
Hvcn1 |
|
| Voltage-gated sodium channels (NaV) | ||||||
| Family name | Physiological ion | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| Voltage-gated sodium channels (NaV) | Na+ | Nav1.1 |
SCN1A |
Scn1a |
Scn1a |
|
| Voltage-gated sodium channels (NaV) | Na+ | Nav1.2 |
SCN2A |
Scn2a |
Scn2a |
|
| Voltage-gated sodium channels (NaV) | Na+ | Nav1.3 |
SCN3A |
Scn3a |
Scn3a |
|
| Voltage-gated sodium channels (NaV) | Na+ | Nav1.4 |
SCN4A |
Scn4a |
Scn4a |
|
| Voltage-gated sodium channels (NaV) | Na+ | Nav1.5 |
SCN5A |
Scn5a |
Scn5a |
|
| Voltage-gated sodium channels (NaV) | Na+ | Nav1.6 |
SCN8A |
Scn8a |
Scn8a |
|
| Voltage-gated sodium channels (NaV) | Na+ | Nav1.7 |
SCN9A |
Scn9a |
Scn9a |
|
| Voltage-gated sodium channels (NaV) | Na+ | Nav1.8 |
SCN10A |
Scn10a |
Scn10a |
|
| Voltage-gated sodium channels (NaV) | Na+ | Nav1.9 |
SCN11A |
Scn11a |
Scn11a |
|
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