Ion channel subunits
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| 5-HT3 receptors | ||||||
| Family name | Ligand | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| 5-HT3 receptors |
5-hydroxytryptamine
|
5-HT3AB | ||||
| 5-HT3 receptors |
5-hydroxytryptamine
|
5-HT3A | ||||
| 5-HT3 receptors |
5-hydroxytryptamine
|
5-HT3A |
HTR3A |
Htr3a |
Htr3a |
|
| 5-HT3 receptors |
5-hydroxytryptamine
|
5-HT3B |
HTR3B |
Htr3b |
Htr3b |
|
| 5-HT3 receptors |
5-hydroxytryptamine
|
5-HT3C |
HTR3C |
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| 5-HT3 receptors |
5-hydroxytryptamine
|
5-HT3D |
HTR3D |
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| 5-HT3 receptors |
5-hydroxytryptamine
|
5-HT3E |
HTR3E |
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| Acid-sensing (proton-gated) ion channels (ASICs) | ||||||
| Family name | Ligand | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| Acid-sensing (proton-gated) ion channels (ASICs) |
H+
|
ASIC1 |
ASIC1 |
Asic1 |
Asic1 |
|
| Acid-sensing (proton-gated) ion channels (ASICs) |
H+
|
ASIC2 |
ASIC2 |
Asic2 |
Asic2 |
|
| Acid-sensing (proton-gated) ion channels (ASICs) |
H+
|
ASIC3 |
ASIC3 |
Asic3 |
Asic3 |
|
| Epithelial sodium channel (ENaC) | ||||||
| Family name | Ligand | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| Epithelial sodium channel (ENaC) | sodium | ENaCαβγ | ||||
| Epithelial sodium channel (ENaC) | sodium | ENaC α |
SCNN1A |
Scnn1a |
Scnn1a |
|
| Epithelial sodium channel (ENaC) | sodium | ENaC β |
SCNN1B |
Scnn1b |
Scnn1b |
|
| Epithelial sodium channel (ENaC) | sodium | ENaC γ |
SCNN1G |
Scnn1g |
Scnn1g |
|
| Epithelial sodium channel (ENaC) | sodium | ENaC δ |
SCNN1D |
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| GABAA receptors | ||||||
| Family name | Ligand | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| GABAA receptors |
GABA
|
GABAA receptor α1 subunit |
GABRA1 |
Gabra1 |
Gabra1 |
|
| GABAA receptors |
GABA
|
GABAA receptor α2 subunit |
GABRA2 |
Gabra2 |
Gabra2 |
|
| GABAA receptors |
GABA
|
GABAA receptor α3 subunit |
GABRA3 |
Gabra3 |
Gabra3 |
|
| GABAA receptors |
GABA
|
GABAA receptor α4 subunit |
GABRA4 |
Gabra4 |
Gabra4 |
|
| GABAA receptors |
GABA
|
GABAA receptor α5 subunit |
GABRA5 |
Gabra5 |
Gabra5 |
|
| GABAA receptors |
GABA
|
GABAA receptor α6 subunit |
GABRA6 |
Gabra6 |
Gabra6 |
|
| GABAA receptors |
GABA
|
GABAA receptor β1 subunit |
GABRB1 |
Gabrb1 |
Gabrb1 |
|
| GABAA receptors |
GABA
|
GABAA receptor β2 subunit |
GABRB2 |
Gabrb2 |
Gabrb2 |
|
| GABAA receptors |
GABA
|
GABAA receptor β3 subunit |
GABRB3 |
Gabrb3 |
Gabrb3 |
|
| GABAA receptors |
GABA
|
GABAA receptor γ1 subunit |
GABRG1 |
Gabrg1 |
Gabrg1 |
|
| GABAA receptors |
GABA
|
GABAA receptor γ2 subunit |
GABRG2 |
Gabrg2 |
Gabrg2 |
|
| GABAA receptors |
GABA
|
GABAA receptor γ3 subunit |
GABRG3 |
Gabrg3 |
Gabrg3 |
|
| GABAA receptors |
GABA
|
GABAA receptor δ subunit |
GABRD |
Gabrd |
Gabrd |
|
| GABAA receptors |
GABA
|
GABAA receptor ε subunit |
GABRE |
Gabre |
Gabre |
|
| GABAA receptors |
GABA
|
GABAA receptor θ subunit |
GABRQ |
Gabrq |
Gabrq |
|
| GABAA receptors |
GABA
|
GABAA receptor π subunit |
GABRP |
Gabrp |
Gabrp |
|
| GABAA receptors |
GABA
|
GABAA receptor ρ1 subunit |
GABRR1 |
Gabrr1 |
Gabrr1 |
|
| GABAA receptors |
GABA
|
GABAA receptor ρ2 subunit |
GABRR2 |
Gabrr2 |
Gabrr2 |
|
| GABAA receptors |
GABA
|
GABAA receptor ρ3 subunit |
GABRR3 |
Gabrr3 |
Gabrr3 |
|
| Glycine receptors | ||||||
| Family name | Ligand | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| Glycine receptors |
glycine
|
glycine receptor α1 subunit |
GLRA1 |
Glra1 |
Glra1 |
|
| Glycine receptors |
glycine
|
glycine receptor α2 subunit |
GLRA2 |
Glra2 |
Glra2 |
|
| Glycine receptors |
glycine
|
glycine receptor α3 subunit |
GLRA3 |
Glra3 |
Glra3 |
|
| Glycine receptors |
glycine
|
glycine receptor α4 subunit (pseudogene in humans) |
GLRA4 |
Glra4 |
Glra4 |
|
| Glycine receptors |
glycine
|
glycine receptor β subunit |
GLRB |
Glrb |
Glrb |
|
| Glycine receptors |
glycine
|
Glycine Receptor (All subtypes) | ||||
| Ionotropic glutamate receptors | ||||||
| Family name | Ligand | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| Ionotropic glutamate receptors |
L-glutamic acid
|
GluA1 |
GRIA1 |
Gria1 |
Gria1 |
|
| Ionotropic glutamate receptors |
L-glutamic acid
|
GluA2 |
GRIA2 |
Gria2 |
Gria2 |
|
| Ionotropic glutamate receptors |
L-glutamic acid
|
GluA3 |
GRIA3 |
Gria3 |
Gria3 |
|
| Ionotropic glutamate receptors |
L-glutamic acid
|
GluA4 |
GRIA4 |
Gria4 |
Gria4 |
|
| Ionotropic glutamate receptors |
L-glutamic acid
|
GluD1 |
GRID1 |
Grid1 |
Grid1 |
|
| Ionotropic glutamate receptors |
L-glutamic acid
|
GluD2 |
GRID2 |
Grid2 |
Grid2 |
|
| Ionotropic glutamate receptors |
L-glutamic acid
|
GluK1 |
GRIK1 |
Grik1 |
Grik1 |
|
| Ionotropic glutamate receptors |
L-glutamic acid
|
GluK2 |
GRIK2 |
Grik2 |
Grik2 |
|
| Ionotropic glutamate receptors |
L-glutamic acid
|
GluK3 |
GRIK3 |
Grik3 |
Grik3 |
|
| Ionotropic glutamate receptors |
L-glutamic acid
|
GluK4 |
GRIK4 |
Grik4 |
Grik4 |
|
| Ionotropic glutamate receptors |
L-glutamic acid
|
GluK5 |
GRIK5 |
Grik5 |
Grik5 |
|
| Ionotropic glutamate receptors |
L-glutamic acid
|
GluN1 |
GRIN1 |
Grin1 |
Grin1 |
|
| Ionotropic glutamate receptors |
L-glutamic acid
|
GluN2A |
GRIN2A |
Grin2a |
Grin2a |
|
| Ionotropic glutamate receptors |
L-glutamic acid
|
GluN2B |
GRIN2B |
Grin2b |
Grin2b |
|
| Ionotropic glutamate receptors |
L-glutamic acid
|
GluN2C |
GRIN2C |
Grin2c |
Grin2c |
|
| Ionotropic glutamate receptors |
L-glutamic acid
|
GluN2D |
GRIN2D |
Grin2d |
Grin2d |
|
| Ionotropic glutamate receptors |
L-glutamic acid
|
GluN3A |
GRIN3A |
Grin3a |
Grin3a |
|
| Ionotropic glutamate receptors |
L-glutamic acid
|
GluN3B |
GRIN3B |
Grin3b |
Grin3b |
|
| IP3 receptor | ||||||
| Family name | Ligand | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| IP3 receptor |
IP3
|
IP3R1 |
ITPR1 |
Itpr1 |
Itpr1 |
|
| IP3 receptor |
IP3
|
IP3R2 |
ITPR2 |
Itpr2 |
Itpr2 |
|
| IP3 receptor |
IP3
|
IP3R3 |
ITPR3 |
Itpr3 |
Itpr3 |
|
| Nicotinic acetylcholine receptors | ||||||
| Family name | Ligand | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| Nicotinic acetylcholine receptors |
acetylcholine
|
nicotinic acetylcholine receptor α1 subunit |
CHRNA1 |
Chrna1 |
Chrna1 |
|
| Nicotinic acetylcholine receptors |
acetylcholine
|
nicotinic acetylcholine receptor α2 subunit |
CHRNA2 |
Chrna2 |
Chrna2 |
|
| Nicotinic acetylcholine receptors |
acetylcholine
|
nicotinic acetylcholine receptor α3 subunit |
CHRNA3 |
Chrna3 |
Chrna3 |
|
| Nicotinic acetylcholine receptors |
acetylcholine
|
nicotinic acetylcholine receptor α4 subunit |
CHRNA4 |
Chrna4 |
Chrna4 |
|
| Nicotinic acetylcholine receptors |
acetylcholine
|
nicotinic acetylcholine receptor α5 subunit |
CHRNA5 |
Chrna5 |
Chrna5 |
|
| Nicotinic acetylcholine receptors |
acetylcholine
|
nicotinic acetylcholine receptor α6 subunit |
CHRNA6 |
Chrna6 |
Chrna6 |
|
| Nicotinic acetylcholine receptors |
acetylcholine
|
nicotinic acetylcholine receptor α7 subunit |
CHRNA7 |
Chrna7 |
Chrna7 |
|
| Nicotinic acetylcholine receptors | nicotinic acetylcholine receptor α8 subunit (avian) | |||||
| Nicotinic acetylcholine receptors |
acetylcholine
|
nicotinic acetylcholine receptor α9 subunit |
CHRNA9 |
Chrna9 |
Chrna9 |
|
| Nicotinic acetylcholine receptors |
acetylcholine
|
nicotinic acetylcholine receptor α10 subunit |
CHRNA10 |
Chrna10 |
Chrna10 |
|
| Nicotinic acetylcholine receptors |
acetylcholine
|
nicotinic acetylcholine receptor β1 subunit |
CHRNB1 |
Chrnb1 |
Chrnb1 |
|
| Nicotinic acetylcholine receptors |
acetylcholine
|
nicotinic acetylcholine receptor β2 subunit |
CHRNB2 |
Chrnb2 |
Chrnb2 |
|
| Nicotinic acetylcholine receptors |
acetylcholine
|
nicotinic acetylcholine receptor β3 subunit |
CHRNB3 |
Chrnb3 |
Chrnb3 |
|
| Nicotinic acetylcholine receptors |
acetylcholine
|
nicotinic acetylcholine receptor β4 subunit |
CHRNB4 |
Chrnb4 |
Chrnb4 |
|
| Nicotinic acetylcholine receptors |
acetylcholine
|
nicotinic acetylcholine receptor γ subunit |
CHRNG |
Chrng |
Chrng |
|
| Nicotinic acetylcholine receptors |
acetylcholine
|
nicotinic acetylcholine receptor δ subunit |
CHRND |
Chrnd |
Chrnd |
|
| Nicotinic acetylcholine receptors |
acetylcholine
|
nicotinic acetylcholine receptor ε subunit |
CHRNE |
Chrne |
Chrne |
|
| P2X receptors | ||||||
| Family name | Ligand | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| P2X receptors |
ATP
|
P2X1 |
P2RX1 |
P2rx1 |
P2rx1 |
|
| P2X receptors |
ATP
|
P2X2 |
P2RX2 |
P2rx2 |
P2rx2 |
|
| P2X receptors |
ATP
|
P2X3 |
P2RX3 |
P2rx3 |
P2rx3 |
|
| P2X receptors |
ATP
|
P2X4 |
P2RX4 |
P2rx4 |
P2rx4 |
|
| P2X receptors |
ATP
|
P2X5 |
P2RX5 |
P2rx5 |
P2rx5 |
Endogenous agonist: ATP at human [...] and mouse [...] P2X5 receptors. |
| P2X receptors |
ATP
|
P2X6 |
P2RX6 |
P2rx6 |
P2rx6 |
|
| P2X receptors |
ATP
|
P2X7 |
P2RX7 |
P2rx7 |
P2rx7 |
|
| ZAC | ||||||
| Family name | Ligand | Official IUPHAR receptor name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
| ZAC |
Zn2+
|
ZAC |
ZACN |
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