Ion Channel List | IUPHAR/BPS Guide to PHARMACOLOGY

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Ion channels
Ion channel list

Ion channel subunits

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5-HT₃ receptors
Family name	Ligand	Official IUPHAR receptor name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
5-HT₃ receptors	5-hydroxytryptamine	5-HT₃AB
5-HT₃ receptors	Ca²⁺ 5-hydroxytryptamine Mg²⁺ Zn²⁺	5-HT₃A
5-HT₃ receptors	5-hydroxytryptamine	5-HT₃A	HTR3A	Htr3a	Htr3a
5-HT₃ receptors	5-hydroxytryptamine	5-HT₃B	HTR3B	Htr3b	Htr3b
5-HT₃ receptors	5-hydroxytryptamine	5-HT₃C	HTR3C
5-HT₃ receptors	5-hydroxytryptamine	5-HT₃D	HTR3D
5-HT₃ receptors	5-hydroxytryptamine	5-HT₃E	HTR3E
Acid-sensing (proton-gated) ion channels (ASICs)
Family name	Ligand	Official IUPHAR receptor name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
Acid-sensing (proton-gated) ion channels (ASICs)	H⁺	ASIC1	ASIC1	Asic1	Asic1
Acid-sensing (proton-gated) ion channels (ASICs)	H⁺	ASIC2	ASIC2	Asic2	Asic2
Acid-sensing (proton-gated) ion channels (ASICs)	H⁺	ASIC3	ASIC3	Asic3	Asic3
Epithelial sodium channel (ENaC)
Family name	Ligand	Official IUPHAR receptor name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
Epithelial sodium channel (ENaC)	sodium	ENaCαβγ
Epithelial sodium channel (ENaC)	sodium	ENaC α	SCNN1A	Scnn1a	Scnn1a
Epithelial sodium channel (ENaC)	sodium	ENaC β	SCNN1B	Scnn1b	Scnn1b
Epithelial sodium channel (ENaC)	sodium	ENaC γ	SCNN1G	Scnn1g	Scnn1g
Epithelial sodium channel (ENaC)	sodium	ENaC δ	SCNN1D
GABA_A receptors
Family name	Ligand	Official IUPHAR receptor name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
GABA_A receptors	GABA 5α-pregnan-3α-ol-20-one tetrahydrodeoxycorticosterone Zn²⁺	GABA_A receptor α1 subunit	GABRA1	Gabra1	Gabra1
GABA_A receptors	GABA 5α-pregnan-3α-ol-20-one tetrahydrodeoxycorticosterone Zn²⁺	GABA_A receptor α2 subunit	GABRA2	Gabra2	Gabra2
GABA_A receptors	GABA 5α-pregnan-3α-ol-20-one tetrahydrodeoxycorticosterone Zn²⁺	GABA_A receptor α3 subunit	GABRA3	Gabra3	Gabra3
GABA_A receptors	GABA 5α-pregnan-3α-ol-20-one tetrahydrodeoxycorticosterone Zn²⁺	GABA_A receptor α4 subunit	GABRA4	Gabra4	Gabra4
GABA_A receptors	GABA 5α-pregnan-3α-ol-20-one tetrahydrodeoxycorticosterone Zn²⁺	GABA_A receptor α5 subunit	GABRA5	Gabra5	Gabra5
GABA_A receptors	GABA 5α-pregnan-3α-ol-20-one tetrahydrodeoxycorticosterone Zn²⁺	GABA_A receptor α6 subunit	GABRA6	Gabra6	Gabra6
GABA_A receptors	GABA	GABA_A receptor β1 subunit	GABRB1	Gabrb1	Gabrb1
GABA_A receptors	GABA	GABA_A receptor β2 subunit	GABRB2	Gabrb2	Gabrb2
GABA_A receptors	GABA	GABA_A receptor β3 subunit	GABRB3	Gabrb3	Gabrb3
GABA_A receptors	GABA	GABA_A receptor γ1 subunit	GABRG1	Gabrg1	Gabrg1
GABA_A receptors	GABA	GABA_A receptor γ2 subunit	GABRG2	Gabrg2	Gabrg2
GABA_A receptors	GABA	GABA_A receptor γ3 subunit	GABRG3	Gabrg3	Gabrg3
GABA_A receptors	GABA	GABA_A receptor δ subunit	GABRD	Gabrd	Gabrd
GABA_A receptors	GABA	GABA_A receptor ε subunit	GABRE	Gabre	Gabre
GABA_A receptors	GABA	GABA_A receptor θ subunit	GABRQ	Gabrq	Gabrq
GABA_A receptors	GABA	GABA_A receptor π subunit	GABRP	Gabrp	Gabrp
GABA_A receptors	GABA	GABA_A receptor ρ1 subunit	GABRR1	Gabrr1	Gabrr1
GABA_A receptors	GABA	GABA_A receptor ρ2 subunit	GABRR2	Gabrr2	Gabrr2
GABA_A receptors	GABA	GABA_A receptor ρ3 subunit	GABRR3	Gabrr3	Gabrr3
Glycine receptors
Family name	Ligand	Official IUPHAR receptor name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
Glycine receptors	Cu²⁺ glycine H⁺ Zn²⁺	glycine receptor α1 subunit	GLRA1	Glra1	Glra1
Glycine receptors	Cu²⁺ glycine Zn²⁺	glycine receptor α2 subunit	GLRA2	Glra2	Glra2
Glycine receptors	Cu²⁺ glycine Zn²⁺	glycine receptor α3 subunit	GLRA3	Glra3	Glra3
Glycine receptors	glycine	glycine receptor α4 subunit (pseudogene in humans)	GLRA4	Glra4	Glra4
Glycine receptors	glycine Zn²⁺	glycine receptor β subunit	GLRB	Glrb	Glrb
Glycine receptors	glycine taurine Zn²⁺	Glycine Receptor (All subtypes)
Ionotropic glutamate receptors
Family name	Ligand	Official IUPHAR receptor name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
Ionotropic glutamate receptors	L-glutamic acid	GluA1	GRIA1	Gria1	Gria1
Ionotropic glutamate receptors	L-glutamic acid	GluA2	GRIA2	Gria2	Gria2
Ionotropic glutamate receptors	L-glutamic acid	GluA3	GRIA3	Gria3	Gria3
Ionotropic glutamate receptors	L-glutamic acid	GluA4	GRIA4	Gria4	Gria4
Ionotropic glutamate receptors	L-glutamic acid	GluD1	GRID1	Grid1	Grid1
Ionotropic glutamate receptors	L-glutamic acid	GluD2	GRID2	Grid2	Grid2
Ionotropic glutamate receptors	L-glutamic acid	GluK1	GRIK1	Grik1	Grik1
Ionotropic glutamate receptors	L-glutamic acid	GluK2	GRIK2	Grik2	Grik2
Ionotropic glutamate receptors	L-glutamic acid	GluK3	GRIK3	Grik3	Grik3
Ionotropic glutamate receptors	L-glutamic acid	GluK4	GRIK4	Grik4	Grik4
Ionotropic glutamate receptors	L-glutamic acid	GluK5	GRIK5	Grik5	Grik5
Ionotropic glutamate receptors	D-aspartic acid D-serine glycine L-aspartic acid L-glutamic acid	GluN1	GRIN1	Grin1	Grin1
Ionotropic glutamate receptors	D-aspartic acid D-serine glycine L-aspartic acid L-glutamic acid	GluN2A	GRIN2A	Grin2a	Grin2a
Ionotropic glutamate receptors	D-aspartic acid D-serine glycine L-aspartic acid L-glutamic acid	GluN2B	GRIN2B	Grin2b	Grin2b
Ionotropic glutamate receptors	D-aspartic acid D-serine glycine L-aspartic acid L-glutamic acid	GluN2C	GRIN2C	Grin2c	Grin2c
Ionotropic glutamate receptors	D-aspartic acid D-serine glycine L-aspartic acid L-glutamic acid	GluN2D	GRIN2D	Grin2d	Grin2d
Ionotropic glutamate receptors	L-glutamic acid	GluN3A	GRIN3A	Grin3a	Grin3a
Ionotropic glutamate receptors	L-glutamic acid	GluN3B	GRIN3B	Grin3b	Grin3b
IP₃ receptors
Family name	Ligand	Official IUPHAR receptor name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
IP₃ receptors	ATP Ca²⁺ IP₃	IP₃R1	ITPR1	Itpr1	Itpr1
IP₃ receptors	Ca²⁺ IP₃	IP₃R2	ITPR2	Itpr2	Itpr2
IP₃ receptors	Ca²⁺ IP₃	IP₃R3	ITPR3	Itpr3	Itpr3
Nicotinic acetylcholine receptors (nACh)
Family name	Ligand	Official IUPHAR receptor name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
Nicotinic acetylcholine receptors (nACh)	acetylcholine	nicotinic acetylcholine receptor α1 subunit	CHRNA1	Chrna1	Chrna1
Nicotinic acetylcholine receptors (nACh)	acetylcholine	nicotinic acetylcholine receptor α2 subunit	CHRNA2	Chrna2	Chrna2
Nicotinic acetylcholine receptors (nACh)	acetylcholine	nicotinic acetylcholine receptor α3 subunit	CHRNA3	Chrna3	Chrna3
Nicotinic acetylcholine receptors (nACh)	acetylcholine	nicotinic acetylcholine receptor α4 subunit	CHRNA4	Chrna4	Chrna4
Nicotinic acetylcholine receptors (nACh)	acetylcholine	nicotinic acetylcholine receptor α5 subunit	CHRNA5	Chrna5	Chrna5
Nicotinic acetylcholine receptors (nACh)	acetylcholine	nicotinic acetylcholine receptor α6 subunit	CHRNA6	Chrna6	Chrna6
Nicotinic acetylcholine receptors (nACh)	acetylcholine	nicotinic acetylcholine receptor α7 subunit	CHRNA7	Chrna7	Chrna7
Nicotinic acetylcholine receptors (nACh)		nicotinic acetylcholine receptor α8 subunit (avian)
Nicotinic acetylcholine receptors (nACh)	acetylcholine	nicotinic acetylcholine receptor α9 subunit	CHRNA9	Chrna9	Chrna9
Nicotinic acetylcholine receptors (nACh)	acetylcholine	nicotinic acetylcholine receptor α10 subunit	CHRNA10	Chrna10	Chrna10
Nicotinic acetylcholine receptors (nACh)	acetylcholine	nicotinic acetylcholine receptor β1 subunit	CHRNB1	Chrnb1	Chrnb1
Nicotinic acetylcholine receptors (nACh)	acetylcholine	nicotinic acetylcholine receptor β2 subunit	CHRNB2	Chrnb2	Chrnb2
Nicotinic acetylcholine receptors (nACh)	acetylcholine	nicotinic acetylcholine receptor β3 subunit	CHRNB3	Chrnb3	Chrnb3
Nicotinic acetylcholine receptors (nACh)	acetylcholine	nicotinic acetylcholine receptor β4 subunit	CHRNB4	Chrnb4	Chrnb4
Nicotinic acetylcholine receptors (nACh)	acetylcholine	nicotinic acetylcholine receptor γ subunit	CHRNG	Chrng	Chrng
Nicotinic acetylcholine receptors (nACh)	acetylcholine	nicotinic acetylcholine receptor δ subunit	CHRND	Chrnd	Chrnd
Nicotinic acetylcholine receptors (nACh)	acetylcholine	nicotinic acetylcholine receptor ε subunit	CHRNE	Chrne	Chrne
P2X receptors
Family name	Ligand	Official IUPHAR receptor name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
P2X receptors	ATP	P2X1	P2RX1	P2rx1	P2rx1
P2X receptors	ATP	P2X2	P2RX2	P2rx2	P2rx2
P2X receptors	ATP	P2X3	P2RX3	P2rx3	P2rx3
P2X receptors	ATP	P2X4	P2RX4	P2rx4	P2rx4
P2X receptors	ATP	P2X5	P2RX5	P2rx5	P2rx5	Endogenous agonist: ATP at human [...] and mouse [...] P2X5 receptors.
P2X receptors	ATP	P2X6	P2RX6	P2rx6	P2rx6
P2X receptors	ATP	P2X7	P2RX7	P2rx7	P2rx7
ZAC
Family name	Ligand	Official IUPHAR receptor name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
ZAC	Cu²⁺ H⁺ Zn²⁺	ZAC	ZACN