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Gene and Protein Information | |||||||
Species | TM | P Loops | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 6 | 1 | 575 | 11p15.4 | CNGA4 | cyclic nucleotide gated channel subunit alpha 4 | |
Mouse | 6 | 1 | 575 | 7 E3 | Cnga4 | cyclic nucleotide gated channel alpha 4 | 1 |
Rat | 6 | 1 | 575 | 1q32 | Cnga4 | cyclic nucleotide gated channel subunit alpha 4 | 3,8 |
Database Links | |
Alphafold | Q8IV77 (Hs), Q3UW12 (Mm), Q64359 (Rn) |
CATH/Gene3D | 2.60.120.10 |
ChEMBL Target | CHEMBL4523657 (Rn) |
Ensembl Gene | ENSG00000132259 (Hs), ENSMUSG00000030897 (Mm), ENSRNOG00000017609 (Rn) |
Entrez Gene | 1262 (Hs), 233649 (Mm), 85258 (Rn) |
Human Protein Atlas | ENSG00000132259 (Hs) |
KEGG Gene | hsa:1262 (Hs), mmu:233649 (Mm), rno:85258 (Rn) |
OMIM | 609472 (Hs) |
Pharos | Q8IV77 (Hs) |
RefSeq Nucleotide | NM_001037329 (Hs), NM_001033317 (Mm), NM_053496 (Rn) |
RefSeq Protein | NP_001032406 (Hs), NP_001028489 (Mm), NP_445948 (Rn) |
UniProtKB | Q8IV77 (Hs), Q3UW12 (Mm), Q64359 (Rn) |
Wikipedia | CNGA4 (Hs) |
Associated Proteins | ||||||||||||||||||||||||
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Activator Comments | ||
CNGA4 confers increased sensitivity to cAMP [3,6,8]. Together with CNGA2, CNGA4 confers sensitivity to cGMP [11]. |
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Physiological Functions | ||||||||
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Phenotypes, Alleles and Disease Models | Mouse data from MGI | ||||||||||||||||||
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1. Berghard A, Buck LB, Liman ER. (1996) Evidence for distinct signaling mechanisms in two mammalian olfactory sense organs. Proc Natl Acad Sci USA, 93 (6): 2365-9. [PMID:8637879]
2. Bradley J, Bönigk W, Yau KW, Frings S. (2004) Calmodulin permanently associates with rat olfactory CNG channels under native conditions. Nat Neurosci, 7 (7): 705-10. [PMID:15195096]
3. Bradley J, Li J, Davidson N, Lester HA, Zinn K. (1994) Heteromeric olfactory cyclic nucleotide-gated channels: a subunit that confers increased sensitivity to cAMP. Proc Natl Acad Sci USA, 91 (19): 8890-4. [PMID:7522325]
4. Bradley J, Reisert J, Frings S. (2005) Regulation of cyclic nucleotide-gated channels. Curr Opin Neurobiol, 15 (3): 343-9. [PMID:15922582]
5. Bradley J, Zhang Y, Bakin R, Lester HA, Ronnett GV, Zinn K. (1997) Functional expression of the heteromeric "olfactory" cyclic nucleotide-gated channel in the hippocampus: a potential effector of synaptic plasticity in brain neurons. J Neurosci, 17 (6): 1993-2005. [PMID:9045728]
6. Bönigk W, Bradley J, Müller F, Sesti F, Boekhoff I, Ronnett GV, Kaupp UB, Frings S. (1999) The native rat olfactory cyclic nucleotide-gated channel is composed of three distinct subunits. J Neurosci, 19 (13): 5332-47. [PMID:10377344]
7. Kelliher KR, Ziesmann J, Munger SD, Reed RR, Zufall F. (2003) Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice. Proc Natl Acad Sci USA, 100 (7): 4299-304. [PMID:12649326]
8. Liman ER, Buck LB. (1994) A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP. Neuron, 13 (3): 611-21. [PMID:7522482]
9. Michalakis S, Reisert J, Geiger H, Wetzel C, Zong X, Bradley J, Spehr M, Hüttl S, Gerstner A, Pfeifer A et al.. (2006) Loss of CNGB1 protein leads to olfactory dysfunction and subciliary cyclic nucleotide-gated channel trapping. J Biol Chem, 281 (46): 35156-66. [PMID:16980309]
10. Munger SD, Lane AP, Zhong H, Leinders-Zufall T, Yau KW, Zufall F, Reed RR. (2001) Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation. Science, 294 (5549): 2172-5. [PMID:11739959]
11. Nache V, Zimmer T, Wongsamitkul N, Schmauder R, Kusch J, Reinhardt L, Bönigk W, Seifert R, Biskup C, Schwede F et al.. (2012) Differential regulation by cyclic nucleotides of the CNGA4 and CNGB1b subunits in olfactory cyclic nucleotide-gated channels. Sci Signal, 5 (232): ra48. [PMID:22786723]
12. Zheng J, Zagotta WN. (2004) Stoichiometry and assembly of olfactory cyclic nucleotide-gated channels. Neuron, 42 (3): 411-21. [PMID:15134638]