Synonyms: compound 2 [PMID: 23124563] | KRP-203 | KRP203
Compound class:
Synthetic organic
Comment: Mocravimod (KRP-203) is a sphingosine 1-phosphate receptor type 1 (S1P1R) agonist with immunomodulatory potential [2]. It is a highly modified analogue of the approved MS drug fingolimod.
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References |
1. Fujishiro J, Kudou S, Iwai S, Takahashi M, Hakamata Y, Kinoshita M, Iwanami S, Izawa S, Yasue T, Hashizume K et al.. (2006)
Use of sphingosine-1-phosphate 1 receptor agonist, KRP-203, in combination with a subtherapeutic dose of cyclosporine A for rat renal transplantation. Transplantation, 82 (6): 804-12. [PMID:17006328] |
2. Shimizu H, Takahashi M, Kaneko T, Murakami T, Hakamata Y, Kudou S, Kishi T, Fukuchi K, Iwanami S, Kuriyama K et al.. (2005)
KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts. Circulation, 111 (2): 222-9. [PMID:15642767] |
3. Takahashi M, Shimizu H, Murakami T, Enosawa S, Suzuki C, Takeno Y, Hakamata Y, Kudou S, Izawa S, Yasue T et al.. (2005)
A novel immunomodulator KRP-203 combined with cyclosporine prolonged graft survival and abrogated transplant vasculopathy in rat heart allografts. Transplant Proc, 37 (1): 143-5. [PMID:15808575] |