trilobatin   Click here for help

GtoPdb Ligand ID: 13073

Synonyms: phloretin-4'-O-glucoside | prunin dihydrochalcone
Immunopharmacology Ligand
Compound class: Natural product or derivative
Comment: Trilobatin is a plant-derived natural product that is found in fruit and tea trees [7], and which has been used as a natural food sweetener. It is structurally and functionally related to phloretin. Trilobatin is suggested to exhibit anti-hyperglycemic [2,5], anti-oxidative [1,8] and anti-inflammatory activities [3-4,6,9].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 10
Hydrogen bond donors 7
Rotatable bonds 7
Topological polar surface area 177.14
Molecular weight 436.41
XLogP 0.5
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES C1=C(C=CC(=C1)O)CCC(=O)C2=C(C=C(C=C2O)O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)O
Isomeric SMILES C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O)O
InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-12-7-14(25)17(15(26)8-12)13(24)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-23,25-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
InChI Key GSTCPEBQYSOEHV-QNDFHXLGSA-N
References
1. Chen N, Wang J, He Y, Xu Y, Zhang Y, Gong Q, Yu C, Gao J. (2020)
Trilobatin Protects Against Aβ25-35-Induced Hippocampal HT22 Cells Apoptosis Through Mediating ROS/p38/Caspase 3-Dependent Pathway.
Front Pharmacol, 11: 584. [PMID:32508629]
2. Chen XM, Yang WQ, Wang X, Chen C, Qian ZM, Wang SM, Tang D. (2022)
Effects of natural dihydrochalcones in sweet tea (Lithocarpus polystachyus) on diabetes: a systematical review and meta-analysis of animal studies.
Food Funct, 13 (11): 5899-5913. [PMID:35583219]
3. Duan YY, Mi XJ, Su WY, Tang S, Jiang S, Wang Z, Zhao LC, Li W. (2022)
Trilobatin, an Active Dihydrochalcone from Lithocarpus polystachyus, Prevents Cisplatin-Induced Nephrotoxicity via Mitogen-Activated Protein Kinase Pathway-Mediated Apoptosis in Mice.
ACS Omega, 7 (42): 37401-37409. [PMID:36312396]
4. Gao J, Chen N, Li N, Xu F, Wang W, Lei Y, Shi J, Gong Q. (2020)
Neuroprotective Effects of Trilobatin, a Novel Naturally Occurring Sirt3 Agonist from Lithocarpus polystachyus Rehd., Mitigate Cerebral Ischemia/Reperfusion Injury: Involvement of TLR4/NF-κB and Nrf2/Keap-1 Signaling.
Antioxid Redox Signal, 33 (2): 117-143. [PMID:32212827]
5. He M, Zhai Y, Zhang Y, Xu S, Yu S, Wei Y, Xiao H, Song Y. (2022)
Inhibition of α-glucosidase by trilobatin and its mechanism: kinetics, interaction mechanism and molecular docking.
Food Funct, 13 (2): 857-866. [PMID:34989743]
6. Hou FQ, Wu XY, Gong MX, Wei JJ, Yi Y, Wei Y, He ZX, Gong QH, Gao JM. (2023)
Trilobatin rescues fulminant hepatic failure by targeting COX2: Involvement of ROS/TLR4/NLRP3 signaling.
Phytomedicine, 120: 155059. [PMID:37672856]
7. Shang A, Liu HY, Luo M, Xia Y, Yang X, Li HY, Wu DT, Sun Q, Geng F, Gan RY. (2022)
Sweet tea (Lithocarpus polystachyus rehd.) as a new natural source of bioactive dihydrochalcones with multiple health benefits.
Crit Rev Food Sci Nutr, 62 (4): 917-934. [PMID:33030031]
8. Xiao R, Wei Y, Zhang Y, Xu F, Ma C, Gong Q, Gao J, Xu Y. (2022)
Trilobatin, a Naturally Occurring Food Additive, Ameliorates Exhaustive Exercise-Induced Fatigue in Mice: Involvement of Nrf2/ARE/Ferroptosis Signaling Pathway.
Front Pharmacol, 13: 913367. [PMID:35814232]
9. Zhang ZT, He WJ, Deng SM, Xu SH, Zeng X, Qian ZM, Chen ZQ, Wang SM, Tang D. (2022)
Trilobatin alleviates non-alcoholic fatty liver disease in high-fat diet plus streptozotocin-induced diabetic mice by suppressing NLRP3 inflammasome activation.
Eur J Pharmacol, 933: 175291. [PMID:36150533]