Compound class:
Synthetic organic
Comment: Compound 6N is reported as a low nanomolar potency agonist of the nuclear hormone receptor, liver receptor homolog-1 (LRH-1; NR5A2) [1]. It does not exhibit agonist activity at the related receptor, steroidogenic factor 1 (SF-1; NR5A1). LRH-1 has no known endogenous ligand.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Mays SG, Flynn AR, Cornelison JL, Okafor CD, Wang H, Wang G, Huang X, Donaldson HN, Millings EJ, Polavarapu R et al.. (2019)
Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design. J Med Chem, 62 (24): 11022-11034. [PMID:31419141] |