Synonyms: ZLN 005 | ZLN-005
Compound class:
Synthetic organic
Comment: ZLN005 acts as a transcriptional activator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α; PPARGC1A) [6]. Activation of the AMP-activated protein kinase pathway is implicated in the induction of PGC-1α expression. ZLN005 appears to produce cytoprotective/neuroprotective actions by enhancing mitochondrial fatty acid oxidation, respiration and biogenesis in a range of cell types and pathologies [1,3-5,7], and attenuating oxidative stress and necroptosis.
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Immunopharmacology Comments |
ZLN005 upregulates PGC-1α expression, and this action attenuates NF-α-induced proinflammatory cytokine expression in vitro [2]. |