Synonyms: Example-6 [WO2020148619A1] | ZY-IL1 | ZYIL-1 | ZYIL1
Compound class:
Synthetic organic
Comment: Usnoflast (ZYIL1) is a novel oral non-steroidal anti-inflammatory compound that acts as a NLRP3 inhibitor [2-3].
|
|
Immunopharmacology Comments |
ZYIL1 is designed to combat pathological NLRP3 inflammasome activation in chronic inflammatory conditions. Mechanistically ZYIL1 inhibits NLRP3 inflammasome pathway activation by preventing NLRP3‐induced ASC oligomerization. It inhibits production of IL-1β and IL-18. |