Synonyms: H 151 | H151
Compound class:
Synthetic organic
Comment: H-151 is a small molecule covalent STING antagonist [2]. Mechanistically it binds to Cys91 of the protein and prevents its palmitoylation. The non-modified STING protein is then unable to assemble the STING complexes that are essential to activate downstream processes (e.g. Type I interferon response). H-151 has been reported to reduce SARS-CoV-2-induced lung inflammation and to improve disease outcome in ACE2-humanised mice [1].
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Immunopharmacology Comments |
H-151 is a covalent STING antagonist that exhibits anti-inflammatory action in vitro and in vivo [2]. The in vitro work confirms that STING antagonism is a tractable approach for the development of novel therapeutic agents for autoinflammatory disease. |