Synonyms: Gaster® | MK-208 | Pepcid®
famotidine is an approved drug (FDA (1986))
Compound class:
Synthetic organic
Comment: Famotidine is a histamine H2 receptor antagonist. The drug is poorly soluble in the low pH of the stomach so suffers from poor bioavailability. Low dose (10-20 mg) famotidine is available over-the-counter in some countries. Marketing of a combination of famotidine with antacids magnesium hydroxide and calcium carbonate (Pepcidtwo®) has been officially discontinued in the UK (2015).
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖View more information in the IUPHAR Pharmacology Education Project: famotidine |
|
No information available. |
Summary of Clinical Use |
Famotidine is used to treat stomach and duodenal ulcers, gastroesophageal reflux, and conditions of over-production of stomach acid. |
Mechanism Of Action and Pharmacodynamic Effects |
Famotidine is a histamine H2 antagonist. Activation of this receptor mediates gastric acid secretion, so antagonism inhibits gastric acid secretion. |
External links |
For extended ADME data see the following: Drugs.com |